Children with congenital heart disease (CHD) remain at high risk for long-term neurodevelopmental disabilities. Acute neurologic complications, such as seizures, transient ischemic attack, intracranial hemorrhage, and stroke may occur in the setting of cardiac surgery catheterization.

Hamza Arman Lateef, Gabriel Ralston, Tony Bright, Aravindh Soundarajan and Jessica Carpenter Epilepsy is a neurologic disease characterized by seizures which occur due to sudden synchronized bursts of excessive electrical energy in the brain.

The paraneoplastic neurologic diseases (PNDs) are brain degenerations that develop in the setting of clinically inapparent cancers. PNDs arise when common cancers express brain proteins, triggering an anti-tumor immune response and tumor immunity. Research on these brain-cancer proteins has revealed a new world of neuron-specific RNA binding proteins whose functions may be aberrantly used by tu...

Brain metastases are the most common cause of malignant brain tumors in adults. Lung and breast cancers are the most common tumors that metastasize to brain, with melanoma, renal, and colorectal cancers accounting for the majority of the remaining metastases [1]. Among human cancers, melanoma has the highest propensity to metastasize to the brain [2]. The relative anatomical distribution of met...

PURPOSE OF REVIEW The landscape of genetic diagnostic testing has changed dramatically with the introduction of next-generation clinical exome sequencing (CES), which provides an unbiased analysis of all protein-coding sequences in the roughly 21,000 genes in the human genome. Use of this testing, however, is currently limited in clinical neurologic practice by the lack of a framework for appro...

The advent of enzyme replacement therapy for AndersonFabry disease (AFD) adds impetus for the early detection of patients with this inherited multiorgan lipid storage disease. The resultant accumulation of neutral glycosphingolipids, especially globotriaosylceramide (Gb3), in various cell types promotes development of disease-related complications associated with renal, cardiovascular, and cere...

Although the issue has not yet been fully resolved, there is reason to believe that TRI-I may have a trophic effect on the normal motoneuron and may transien­ tly improve the neurologic deficit in ALS. Since ALS is not a simple TRI-I deficiency disease, this improvement probably occurs via a secondary mecha -nism-possibly another neurotransmitter. It is uncertain at this time whether this effec...

sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. the aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. these group...

Word-finding difficulty’ (WFD)is an expressive speech disorder that can result from a wide range of neurologic disturbances. It be the multiple brain disorders such as infraction [1], epilepsy [2] infectious disease [3] or even sclerosis [4].