Although a number of neuromodulators influence the cerebellar circuitry, their functions remain largely unknown. By reviewing and combining results from data-driven and theory-driven studies, we attempt to provide an integrated systems view of cerebellar neuromodulation. First, we review the short- and long-term effects of neuromodulators on the cerebellar circuitry. Second, we review recent th...

This paper explores the implications of certain new developments in cell biology upon neuroscience. Until recently it was thought that neurotransmitters and neuromodulators had only one function, which was to stimulate their specific receptors at the cell surface. From here on, all activity was supposed to be effected by postsynaptic cascades. The discovery that membrane components, particularl...

Learning recurrent neural networks as behavior controllers for robots requires measures to guide the learning towards a desired behavior. Organisms in nature solve this problem with feedback signals to assess their behavior and to refine their actions. In line with this, a neural framework is developed where the synaptic learning is controlled by artificial neuromodulators that are produced in ...

Wakefulness is driven by the widespread release of neuromodulators by the ascending arousal system. Yet, it is unclear how these substances orchestrate state-dependent, global changes in neuronal activity. Here, we show that neuromodulators induce increases in the extracellular K(+) concentration ([K(+)]e) in cortical slices electrically silenced by tetrodotoxin. In vivo, arousal was linked to ...

Neuromodulators including acetylcholine, norepinephrine, serotonin, dopamine and a range of peptides alter the processing characteristics of cortical networks through effects on excitatory and inhibitory synaptic transmission, on the adaptation of cortical pyramidal cells, on membrane potential, on the rate of synaptic modification, and on other cortical parameters. Computational models of self...

Neuromodulators such as acetylcholine, serotonin, and noradrenaline are powerful regulators of neocortical activity. Although it is well established that cortical inhibition is the target of these modulations, little is known about their effects on GABA release from specific interneuron types. This knowledge is necessary to gain a mechanistic understanding of the actions of neuromodulators beca...

Neural processing faces three rather different, and perniciously tied, communication problems. First, computation is radically distributed, yet point-to-point interconnections are limited. Second, the bulk of these connections are semantically uniform, lacking differentiation at their targets that could tag particular sorts of information. Third, the brain's structure is relatively fixed, and y...

Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders whose diagnosis exclusively made on behavioral basis. According to the diagnostic and statistical manual mental disorders, autism defined by deficits in two main symptoms (social interaction & communication, repetitive/restrictive behaviors), which emerge premature phases postnatal development. The authors rev...