Aging is known to play a critical role in the etiopathogenesis of several diseases. Among them, cardiovascular disorders are especially relevant since they becoming first cause death western countries. Resveratrol polyphenolic compound that has been shown exert beneficial effects at different levels, including neuronal and protection. Those resveratrol related, least part, its antioxidant anti-...

Incidence of anxiety-like disorders in humans has been shown to decrease with aging; however, it is still under debate whether there are similarities mice, which would support the use mouse models understanding neuronal network changes that regulate behavior aging. One most common tests used assess laboratory animals elevated plus maze (EPM). Although several variables, such as room brightness ...

Background Gastrodin can reduce neuronal damage through multiple targets and pathways, be useful in preventing treating degenerative lesions of the central nervous system, but specific mechanism has not been elucidated. Methods The aging-related genes hippocampus frontal cortex were detected adult aged mice treated with gastrodin or not. In addition, we collected target aging from a network dat...

multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...

What is the neurocognitive basis for the considerable individual differences observed in functioning of the adult mind and brain late in life? We review the evidence that in healthy old age the brain remains capable of both neuronal and cognitive plasticity, including in response to environmental and experiential factors. Neuronal plasticity (e.g., neurogenesis, synaptogenesis, cortical re-orga...

Degenerative changes during aging have been identified in the inner ear and in the vestibular nerve, but not in the human vestibular nuclear complex (VNC). Therefore, the purpose of this study was to document quantitative morphometric changes within the VNC in humans as a function of age. The VNC of normal human subjects was examined for age-related changes using computer-based microscopy. Neur...