The neuropharmacological effect of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the rhizome of Drynaria quercifolia J. Smith were studied in mice by intraperitoneal administration. The tests used were determination of effect on duration of diazepam-induced sleep, determination of effect on nikethamide-induced toxicity, light-dark test and force swimming test. The du...

objective: parkia biglobossa stem bark decoction is a popular medicinal plant preparation used as calming agent for tensed patients in traditional medicine. the aim of this study was to evaluate the effects of aqueous stem bark extract of parkia biglobossa (aepb) and its active fraction aepbf3 on anxiety, spontaneous alternation behavior, and locomotor activity. the open field apparatus was use...

To the Editor: We read with great interest the article by Krause et al. (1). They report on the role played by activated natural killer cells in the treatment of colon and lung cancer patients. With respect to the above, we would like to inform readers of our experience with this issue. In 1987, we found that neuropharmacological therapy was able to improve different types of cancer patients (2...

Despite an abundance of information on clinical and experimental epilepsy and on the drugs effective in its treatment, we 3rc still without a full undentanding of the inherent etiology of the epileptogenic focus and the mechanism of action of anticonvulsant drugs. In recent years allcolion has therefore been mainly directed towards the elucidation of these factors on a neuropharmacological and ...

The dichloromethane fraction of Hedranthera barteri (DMHBR), a common medicinal plant, was investigated in animal models of depression and anxiety in mice. Graded doses (25-200mg/kg p.o. bw) of DMHBR reduced the immobility time with significant effects produced by 50mg/kg (43.7%), 100mg/kg (45.6%) and 200mg/kg (31.5%) in the tail suspension test (TST) and by 100mg/kg (66.3%) in forced swimming ...

Psychoactive bath salts (also called meph, drone, meow meow, m-CAT, bounce, bubbles, mad cow, etc.) contain a substance called mephedrone (4-methylcathinone) that may share psychostimulant properties with amphetamine and cocaine. However, there are only limited studies of the neuropharmacological profile of mephedrone. The present study used an established invertebrate (planarian) assay to test...

The ontogenetic course of two cholinergically mediated central neuropharmacological effects, yawning and potentiation of head-shaking induced by D-amphetamine (5 mg/kg), was explored in developing rats. Physostigmine (0.1 mg/kg) and pilocarpine (4 mg/kg) evoke stereotyped yawning in neonatal rats, the effect declining in the middle of the second week of life. Both cholinomimetic drugs strongly ...

Clinical, genetic, and neuropsychopharmacological studies ofdevelopmental factors in alcoholism are providing a better understanding of the neurobiological bases of personality and learning. Studies of the adopted-away children of alcoholics show that the predisposition to initiate alcohol-seeking behavior is geneticaily different from susceptibility to loss of control after drinking begins. Al...

The present study was carried out to evaluate CNS activity of ethanolic extract of roots of Anacyclus pyrethrum that includes general behavior studies, sedative, muscle relaxant, anxiolytic, nootropic activity and antidepressant studies in rats. The results reveal potential neuropharmacological activity of Anacyclus pyrethrum as nootropic and also having antidepressant property. Further neuroch...