Citation: Rubia K (2018) Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation. Front. Hum. Neurosci. 12:100. doi: 10.3389/fnhum.2018.00100 This review focuses on the cognitive neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) based on functional magnetic resonance imaging (fMRI) studies and on recent clinically relevant application...

Objective To assess whether cervical spinal cord atrophy heralds the onset of progressive MS. Methods We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average seg...

UNLABELLED A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related factor 2 (Nrf2)/antioxidant response element signaling, which regulates expression of antioxidant, anti-inflammatory, and cytoprotective genes. Tecfidera, a putative Nrf2 activator, is an oral formulation of dimethylfumarate (DMF) used to treat multiple sclerosis. We compared the effects of DM...

Tremor disorders pose fundamental questions about disease mechanisms, and challenges to successful neurotherapeutics: What causes motor circuits to oscillate in disorders in which the central nervous system otherwise seems normal? How does inheritance 'determine' the clinical phenotype in familial tremor disorders? Here, we address these questions. Analogies between the neural circuits controll...

Copyright © 2016 Etienne de Villers-Sidani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The remarkable plastic nature of our brain, often manifesting itself via changes in how brain circuits code information, is at the o...

Introduction: The corpus callosum (CC) plays an important role in relaying sensory, motor and cognitive function between the cerebral hemispheres. Females seem to employ a greater degree of bilateral hemispheric activity than males (1) and also have a larger callosal area in proportion to brain volume (2) which suggests that a larger number of fibres are passing through. We have previously show...

Randomized controlled trials are the essential evidence on which to judge the efficacy of a treatment. All new antiepileptic drugs (AEDs) or devices have been marketed only after rigorous randomized controlled trials. The most common designs for initial AED efficacy trials are “add-on” trials in which patients with refractory epilepsy receiving stable AED therapy are randomized to addition of a...

Back to table of contents Previous article Next CommentaryFull AccessElectroconvulsive Therapy Is an Essential ProcedureDaniel F. Maixner, M.D., Richard Weiner, Ph.D., Irving M. Reti, M.B.B.S., Adriana P. Hermida, Mustafa Husain, Dane Larsen, B.A., William McDonald, M.D.Daniel MaixnerSearch for more papers by this author, WeinerSearch RetiSearch HermidaSearch HusainSearch LarsenSearch McDonaldS...

PRESENTATIONDAY 1 1 CLINICAL RESPONSE OF NEUROMUSCULAR PATIENTS TO IVIG: AN INTERIM ANALYSIS OF THE INSIGHTS REGISTRY T. Levine, J. Katz, R. Barohn, T. Mozaffar, G. Wolfe, D. Saperstein, L. Katzin, M. Dimachkie, E. Ritt, L. Vaughan, M. Greer (Phoenix Neurological Associates; California Pacific Medical Center; University of Kansas; University of California, Irvine; University at Buffalo; Univers...