نتایج جستجو برای: neurotrophins 4
تعداد نتایج: 1305045 فیلتر نتایج به سال:
The NTRK3 gene (also known as TRKC) encodes a high affinity receptor for the neurotrophin 3'-nucleotidase (NT3), which is implicated in oligodendrocyte and myelin development. We previously found that white matter integrity in young adults is related to common variants in genes encoding neurotrophins and their receptors. This underscores the importance of neurotrophins for white matter developm...
In the central nervous system (CNS), the expression of molecules is strictly regulated during development. Control of the spatiotemporal expression of molecules is a mechanism not only to construct the functional neuronal network but also to adjust the network in response to new information from outside of the individual, i.e., through learning and memory. Among the functional molecules in the ...
ÐMigration of the granule cells is a major stage of cerebellar maturation. Granule cells express neurotrophins and their receptors; however, their role in cell migration has not been de®ned. In this study we investigated the effects of exogenous neurotrophins on the movement and neurite extension of granule cells from glial-free cerebellar cell reaggregates in vitro. Our results provide direct ...
Neurotrophins are a family of soluble ligands that promote the survival and differentiation of peripheral and central neurons and regulate synaptic function. The two neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), bind and activate a single high-affinity receptor, TrkB. Experiments in cell culture have revealed that an intact Shc adaptor binding site on TrkB an...
Neurotrophins are critically involved in developmental processes such as neuronal cell survival, growth, and differentiation, as well as in adult synaptic plasticity contributing to learning and memory. Our previous studies examining neurotrophins and memory formation in Aplysia showed that a TrkB ligand is required for MAPK activation, long-term synaptic facilitation (LTF), and long-term memor...
The increased prevalence of neurodegenerative diseases, especially during the COVID-19 outbreak, necessitates search for natural immune- and cognitive-enhancing agents. 10-Hydroxy-trans-2-decenoic acid (10-H2DA), main fatty royal jelly, has several pharmacological activities. Given fundamental role astrocytes in regulating immune responses central nervous system, we used cortical to examine eff...
Neurotrophins constitute a group of growth factor that exerts important functions in the nervous system vertebrates. They act through two classes transmembrane receptors: tyrosine-kinase receptors and p75 neurotrophin receptor (p75NTR). The activation p75NTR can favor cell survival or apoptosis depending on diverse factors. Several studies evidenced link between pathogenesis prion diseases. In ...
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