INTRODUCTION — Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in the newborn infant. It is a disorder characterized by ischemic necrosis of the intestinal mucosa, which is associated with inflammation, invasion of enteric gas forming organisms, and dissection of gas into the muscularis and portal venous system [1]. Although early recognition and aggressiv...

Clinical pulmonary surfactant is routinely used to treat premature newborns with respiratory distress syndrome, and has shown great potential in alleviating a number of neonatal and adult respiratory diseases. Despite extensive study of chemical composition, surface activity, and clinical performance of various surfactant preparations, a direct comparison of surfactant films is still lacking. I...

BACKGROUND The nutrition and epidemiologic transition has been associated with an increasing incidence of preterm birth in developing countries, but data from large observational studies in China have been limited. Our study was to describe the trends and factors associated with the incidence of preterm birth and infant mortality due to prematurity in Hubei Province, China. METHODS We conduct...

Smoking during pregnancy is associated with various adverse effects on pregnancy and fetal development, carries a lot of serious complications such as spontaneous abortion, placental abruption, and reduced birth weight of the newborn. Children of smoking mothers have an increased risk of premature birth, low birth weight, sudden infant death syndrome and respiratory diseases during infancy. Smo...

Urgent action is needed to address preterm birth given that the fi rst country-level estimates show that globally 15 million babies are born too soon and rates are increasing in most countries with reliable time trend data. As the fi rst in a supplement entitled “Born Too Soon”, this paper focuses on the global policy context. Preterm birth is critical for progress on Millennium Development Goa...

Introduction: Abnormal pregestational and gestational maternal nutritional status is an undeniable health problem which can result in changes interfere fetal conditions. Objective: To analyze the influence of pre-pregnancy on mother-newborn pair outcomes. Methods: This observational, analytical, cross-sectional study carried out a public Maternity Hospital Joinville, SC, Brazil. A total 1,670 p...

Congenital syphilis occurs when Treponema pallidum crosses the placenta during pregnancy or from contact with an infectious genital lesion during delivery. Cutaneous manifestations of congenital syphilis are relatively common, occurring in approximately 30% to 70% of patients. Maculopapular lesions, vesiculobullous lesions, condylomata lata lesions, annular lesions, and erythema multiforme-like...

The concentrating ability of the kidney changes with age: after birth it increases (Smith, 1959), and in old age it falls (Lindeman, van Buren, and Raisz, 1960). The maximum osmolality during the newborn period is much lower than in adults (Heller, 1944; Smith, Yudkin, Young, Minkowski, and Cushman, 1949; Barnett and Vesterdal, 1953; Hansen and Smith, 1953; McCance and Widdowson, 1954; Calgagno...

Critical aortic valve stenosis in newborns is the cause of a severe clinical condition with onset symptoms during first hours after birth. We present case successful surgical correction critical using hybrid method applied newborn day life. The infant was diagnosed hypoplastic left heart complex an intact atrial septum (aortic and mitral valves variant), that led to cardiogenic shock acute pulm...

The relationship between the concentration of cell-free DNA (cfDNA) and the number of proliferating/apoptotic lymphocytes in peripheral blood of premature newborns of different gestation age and full-term newborns was determined. The experiments were performed using fluorescent spectrophotometry (with Hoechst 33342), flow cytometry, and microscopy (Feulgen staining of lymphocytes). It was deter...