the aim of the present work was to assess the feasibility of accononmc8-2ep/nf as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. modified emulsion-solvent diffusion method was employed for the preparation of microsponges (f1-f9) based on 32 factorial design. the amount of ethyl cellulose (ec) and polyvinyl alcohol (pva) were selected as inde...

objective(s): to study the effect of cardiopulmonary bypass (cpb) on nuclear factor-kappa b (nf-кb) and cytokine expression and pulmonary function in dogs. materials and methods: twelve male mongrel dogs were divided into a methylprednisolone group (group m) and a control group (group c). all animals underwent aortic and right atrial catheterization under general anesthesia. changes in pulmonar...

alcoholic liver disease (ald) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. the etiopathogenesis of ald is related to ethanol-induced oxidative stress, glutathione reduction, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate kupffer cells. curcumin is an active ingredient of the rhizome of turmeric. the...

Anion modification and trace metal doping have been widely demonstrated to unique advantages in regulating both electrocatalytic activity the electronic structure of non-precious materials. Developing a simple practical preparation strategy is critical, but it still faces challenges. In this paper, novel type dual-modification approach put forward rationally design S, Pt-CoNi material, which ca...

Phase sensitive amplifiers (PSA), contrary to usual phase insensitive (PIA), are in principle capable achieve noiseless amplification, i.e. exhibit a quantum-limited noise figure (NF) of 0 dB. When implemented using four-wave mixing (FWM) nonlinear fiber, extra waves can be generated by undesired FWM processes, which may introduce input ports for vacuum fluctuations, thus potentially degrading ...

Abstract Humanity is facing a global challenge of dwindling water resources and the situation intensifying due to growing population leading excessive pollution. Nanofiltration an important membrane-based technology for production clean potable domestic industrial setups. Hyper-cross-linked polyamide thin film composite nanofiltration (HCPA-TFC-NF) membranes have been fabricated by using multif...

Dendrites play important roles in neuronal function. However, the cellular mechanism for the growth and maintenance of dendritic arborization is unclear. Neurofilaments (NFs), a major component of the neuronal cytoskeleton, are composed of three polypeptide subunits, NF-H, NF-M, and NF-L, and are abundant in large dendritic trees. By overexpressing each of the three NF subunits in transgenic mi...

objective(s): the objective of this study was to investigate the hepatoprotective effect of licochalcone b (lcb) in a mice model of carbon tetrachloride (ccl4)-induced liver toxicity. materials and methods: hepatotoxicity was induced in mice by a single subcutaneous injection (sc) of ccl4. the lcb was administered orally once a day for seven days (po) as pretreatment at three doses of 1, 5, and...

Nuclear Factor Y (NF-Y) is a heterotrimeric transcription factor that binds CCAAT elements. The NF-Y trimer is composed of a Histone Fold Domain (HFD) dimer (NF-YB/NF-YC) and NF-YA, which confers DNA sequence specificity. NF-YA shares a conserved domain with the CONSTANS, CONSTANS-LIKE, TOC1 (CCT) proteins. We show that CONSTANS (CO/B-BOX PROTEIN1 BBX1), a master flowering regulator, forms a tr...

Neurofilaments (NFs), which are composed of NF-L, NF-M, and NF-H, are required for the development of normal axonal caliber, a property that in turn is a critical determinant of axonal conduction velocity. To investigate how each subunit contributes to the radial growth of axons, we used transgenic mice to alter the subunit composition of NFs. Increasing each NF subunit individually inhibits ra...