known cholesterol-associated drug while also lowering triglycerides, total cholesterol, and very-low-density lipoprotein. However, there are many more uses for niacin, which have been overlooked by conventional mediAbstract A reduced niacin-mediated !ush is increasingly accepted today as a positive diagnostic indicator for schizophrenia. Schizophrenics that were successfully treated with high d...

BACKGROUND An extended-release niacin product (Niaspan, Abbott Laboratories) was identified as a product with a less costly therapeutic alternative; a therapeutic product interchange was implemented. OBJECTIVE To evaluate the efficacy and safety of a product therapeutic interchange from Niaspan to a controlled-release niacin product (Slo-Niacin, Upsher-Smith Laboratories) among patients at a ...

It has been shown that, when tryptophan is administered to rats, an increased excretion of niacin and some of its derivatives occurs (l-4). Isotope studies by Heidelberger et al. (5, 6) have given further evidence that niacin can be derived from tryptophan in the animal body. Vitamin Bs has been implicated in this transformation, since in a pyridoxine deficiency the excretion of an abnormal met...

Nicotinic acid (niacin) has been shown to decrease myocyte injury. Because interventions that lower the cytosolic NADH/NAD(+) ratio improve glycolysis and limit infarct size, we hypothesized that 1) niacin, as a precursor of NAD(+), would lower the NADH/NAD(+) ratio, increase glycolysis, and limit ischemic injury and 2) these cardioprotective benefits of niacin would be limited in conditions th...

cystoid macular edema is a condition that involves the macula, caused by an accumulation of extracellular fluid in the macular region with secondary formation of multiple cystic spaces. this condition is provoked by a variety of pathological conditions such as intraocular inflammation, central or branch retinal vein occlusion, diabetic retinopathy and most commonly following cataract extraction...

introduction: the interest in probiotic products have been increased recently by the consumers. milk and dairy products are natural sources of b group vitamins in the human diet. this study was carried out in order to investigate the level of riboflavin (vitamin b2) and niacin (vitamin b3) in probiotic yogurt and the results were compared with the traditional yogurt during refrigerated storage....

Nicotinic acid widely known as Niacin are also known as vitamin B3 and vitamin PPis an organic compound with the formula C5H4NCO2H which is present in forty to eighty essential human nutrients. This colourless and water-soluble solid is a derivative of pyridine, with a carboxyl group (COOH) at the 3-position. Niacin was first described by Hugo Weidel in 1873 in his studies of nicotine [1]. Mild...

NAD is biosynthesized from tryptophan. Therefore, experimental studies including tryptophan metabolism studies could provide insight into niacin nutrition in pregnancy. Our aim was to determine the change in niacin metabolism during pregnancy by a systemic investigation of how pregnancy alters the tryptophan-niacin metabolism in Japanese women and rats. For the human study, spot urine samples w...

INTRODUCTION A rich and natural source of readily assimilated dietary protein together with invaluable vitamins and minerals are fish, particularly the saltwater species. The quality of any given foodstuff is determined by its nutritional value, which in turn depends on the food type and methods used for manufacture, processing and storage. Many fish products contain fewer water soluble vitamin...

Considerable evidence has been obtained that 3-hydroxyanthranilic acid and quinolinic acid can be converted to niacin in the intact rat (2-9). The usually low yield of niacin from these compounds suggested that another pathway from tryptophan to niacin might exist. Thus, kynurenine or hydroxykynurenine might be converted to niacin through an intermediate such as y-(3-pyridyl)-y-oxo-ar-aminobuty...