Krehl et al. (1,2) have observed a growth retardation in rats when large amounts of corn grits were included in a low protein ration. The addition of either Z(-)-tryptophane or nicotinic acid corrected the deficiency and allowed normal growth to proceed. The beneficial action of tryptophane has also been observed in nicotinic acid deficiency in the chick (3) and the mouse (4). Although recent r...

Raman and FTIR spectra of nicotinic acid have been analysed using ab-initio and DFT calculations. Four stable structures were found for nicotinic acid, the structures differ in orientation of COOH with respect to the nitrogen atom. The optimized geometries, harmonic vibrational wave number, structural parameters and intensities of the nicotinic acid have been calculated using MP2/6-311++G(d,p),...

It has been shown by Krehl et aZ.l that tryptophane may replace nicotinic acid as a growth factor for rats receiving a corn diet. Rosen et al2 have demonstrated that the administration of tryptophane to rats increases the excretion of nicotinic acid derivatives. Experiments reported here with human subjects show that the administration of tryptophane leads to an increased excretion of N1-methyl...

viously reported (Paine et al., 1979b), in the loss of 60% of their total nucleotide content, which is due to a loss of NAD+ and NADH (referred to as NAD throughout) (Table 1). Culture of hepatocytes for 24 h in media containing hyperphysiological concentrations of known precursors of NAD (Ijichi et al., 1966; Blake et al., 1967) shows that only culture medium containing nicotinamide is able to...

When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...

When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...

The mechanisms for the hypolipidemic action of nicotinic acid were examined in 12 patients with hyperlipidemia. Most patients were studied in the hospital on a metabolic ward. The first month was a control period followed by 1 month on nicotinic acid. During treatment with nicotinic acid, the triglycerides (TG) decreased in total plasma by an average of 52% and in very low density lipoproteins ...

An enzyme that catalyzes the reversible hpdroxylation of nicotinic acid to 6-hydroxynicotinic acid has been purified from extracts of a nicotinic acid-fermenting clostridium. The enzyme appears to be a flavin adenine dinucleotidecontaining non-heme iron protein and utilizes triphosphopyridine nucleotide as the ultimate electron acceptor. The purified enzyme also exhibits reduced triphosphopyrid...

SERUM cholesterol is lowered by oral nicotinic acid in the human and in the rabbit. ' The fall in serum cholesterol is roughly proportional to the initial elevation and the amount of nicotinic acid required to produce striking changes in the serum is rather large. These observations pertaining to serum cholesterol assume more importance if they are accompanied by changes in tissue cholesterol. ...

A chemically defined medium (CC-494M) was used to study the vitamin requirements of three spiroplasmas representing three distinct serogroups: flower spiroplasmas [Spiroplasma floricola and FS (SR-3)] and honeybee spiroplasma [HBS (AS-576)]. Nicotinic acid and riboflavin were essential to spiroplasma growth. Nicotinamide could substitute for nicotinic acid. Populations of S. floricola, FS (SR-3...