Fluorescence lifetime imaging (FLi) could potentially improve exogenous near-infrared (NIR) fluorescence imaging, because it offers the capability of discriminating a signal of interest from background, provides real-time monitoring of a chemical environment, and permits the use of several different fluorescent dyes having the same emission wavelength. We present a high-power, LED-based, NIR li...

Metal-based nanomaterials with shifting or mixed redox states have been widely applied for combating against bacteria-infected diseases by virtue of their peroxidase (POD)-like catalytic activity. Herein, a polyoxometalate-based heterojunction (GdP5W30@WS2) (W6+/W5+) is devised to achieve boosted reactive oxygen species (ROS) generation near-infrared (NIR) laser-facilitated W6+/W5+ cycling acce...

Ultrashort femtosecond pulsed lasers may provide indispensable benefits for medical bioimaging and diagnosis, particularly for noninvasive biopsy. However, the ability of femtosecond laser irradiation to produce biodamage in the living body is still a concern. To solve this biosafety issue, results of theoretical estimations as well as the in vitro and in situ experiments on femtosecond biodama...

sama Mahmood lbert Cerussi eza Dehdari uoc Nguyen imothy Kelley ruce Tromberg rian Wong niversity of California at Irvine epartment of Biomedical Engineering and epartment of Otolaryngology—Head and Neck Surgery eckman Laser Institute 002 Health Sciences Road rvine, California 92612 Abstract. Diagnosing sinusitis remains a challenge for primary care physicians. There is a need for a simple, off...

Photodynamic therapy (PDT) is an emerging and promising modality for the treatment of cancer. PDT is based on the concept that photosensitizers can be preferentially localized in tumour tissues upon systemic administration. Irradiation with an appropriate wavelength of light excites these molecules to transfer their energy to molecular oxygen in their surroundings, resulting in the formation of...

The nonlinear mixing of near-infrared (NIR) and terahertz (THz) laser beams is investigated experimentally in a square GaAs quantum well structure, where the symmetry of the sample can be controlled by applying an electric field along the growth direction. The mixing produces sidebands, which appear at sideband= NIR +n THz, where n= ±1,2 , . . .. For a given THz frequency, the intensity of the ...

Smart nanoparticles (NPs) that respond to external and internal stimulations have been developing to achieve optimal drug release in tumour. However, applying these smart NPs to attain high antitumour performance is hampered by limited drug carriers and inefficient spatiotemporal control. Here we report a noninvasive NIR-driven, temperature-sensitive DI-TSL (DOX/ICG-loaded temperature sensitive...

Stimuli-responsive materials are promising as smart materials for a range of applications. In this work, a photo-crosslinkable, thermoresponsive macromer was electrospun into fibrous scaffolds containing gold nanorods (AuNRs). The resulting fibrous nanocomposites composed of poly(N-isopropylacrylamide-co-polyethylene glycol acrylate) (PNPA) and PEGylated AuNRs were crosslinked and swollen in wa...

In this study, the photothermal effect of magnetic nanoparticle clusters was firstly reported for the photothermal ablation of tumors both in vitro in cellular systems but also in vivo study. Compared with individual magnetic Fe3O4 nanoparticles (NPs), clustered Fe3O4 NPs can result in a significant increase in the near-infrared (NIR) absorption. Upon NIR irradiation at 808 nm, clustered Fe3O4 ...

Angiogenesis, the process of new blood vessel formation, is an important therapeutic target in cardiovascular and malignant diseases for diverse reasons. Molecular imaging for angiogenesis has been attracted due to the use of anti-angiogenic therapeutic drugs to treat tumours, and of therapeutic angiogenesis induction to treat vascular diseases. We developed a novel biosensor of imaging microRN...