Case presentation: Female, 8 years old, with onset of seizures at 2 months, evolving refractory epilepsy. The were characterized by behavioral arrest and vacant gaze, in addition to episodes loss tone head turn the right intense salivation. Patient has used topiramate, nitrazepam, carbamazepine valproate. On examination, he is moderately mentally retarded does not speak. Prolonged videoelectroe...

Inexpensive, rapid, and reliable methods of detection are crucial to the control of toxicological investigations. Here we report a highly sensitive, selective and cost effective method for the detection of trace amounts of clonazepam based on gold nanoparticles (AuNPs) in the presence of melamine. Hydrogen bonding interactions between clonazepam and melamine resulted in the aggregation of AuNPs...

In recent years several new benzodiazepine derivatives have been developed in the search for chemical agents with effective hypnotic activity but which do not produce unwanted residual effects. This development has great social implications, especially in societies where transportation mainly relies upon private cars: a state of continual alertness is of critical importance when driving a car. ...