نتایج جستجو برای: nitroso
تعداد نتایج: 2476 فیلتر نتایج به سال:
We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds bioactivated by human cytochrome P450 enzymes.
The potent and selective Cyclin-Dependent Kinase 2 (CDK2) inhibitor NU6027 (6-cyclohexylmethoxy-5nitroso-2,4-diaminopyrimidine) was used as the lead for the synthesis of a series of analogues in order to provide further insights into the structure activity relationships for 2,4-diaminopyrimidine CDK2 inhibitors. Aliphatic amino substituents were introduced at position 2. The use of linear or le...
Electrochemistry is a valuable tool used by modern synthetic chemists who use electricity to facilitate redox reactions. In this image, created Karrar Nadhom, the dragon provides electrical surge create reaction between sodium nitrite and secondary amine, which are fused form N-nitroso product. Despite dragons being extinct in most parts of world, title an ecologically green process, as indicat...
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a widely used explosive that is present in soils at a number of military sites, including training and testing ranges. Because of its relatively weak adsorption to soil, RDX frequently migrates through the unsaturated zone and causes groundwater contamination. In the environment, RDX can transform to produce mono-, di-, and tri-nitroso derivative...
Nitrosamine impurities are potentially genotoxic which considered under cohort of concern as per ICH M7 guidelines and need to be controlled at trace levels during quantification in drug substances products for safe human consumption. Recent regulatory requirements also suggest the have highly sensitive analytical methods accurate impurities. In this paper we presented simple, rapid ultra-sensi...
Turtles of the genus Trachemys show a remarkable ability to survive prolonged anoxia. This is achieved by a strong metabolic depression, redistribution of blood flow and high levels of antioxidant defence. To understand whether nitric oxide (NO), a major regulator of vasodilatation and oxygen consumption, may be involved in the adaptive response of Trachemys to anoxia, we measured NO metabolite...
Purpose:PARP inhibitors are beingdeveloped as therapeutic agents for cancer.More than six compounds have entered clinical trials. The majority of these compounds are b-nicotinamide adenine dinucleotide (NADþ)-competitive inhibitors. One exception is iniparib, which has been proposed to be a noncompetitive PARP inhibitor. In this study, we compare the biologic activities of two different structu...
BACKGROUND 1,4-Diazepine derivatives are the seven membered, nitrogen containing heterocyclic ring systems possessing a wide range of therapeutic applications. 1,4-Diazepines attracted the attention of chemists and druggists due to their biological and medicinal properties, such as antimicrobial, anti-HIV and anticancer activities. Herein, we report the preparation, crystal structure determined...
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