We report a case of a 58-year-old woman with a true non secretory multiple myeloma of the producer type relapsing after many lines of therapy including the novel anti-myeloma drugs, which eventually relapsed as extramedullary liver plasmacytomas manifesting as a fatal acute cholestatic hepatitis. Due to the aggressiveness of this disease, new therapeutic modalities are necessary.

Abstract Oncogene-induced senescence provides a barrier against malignant transformation. However, it can also promote cancer through the secretion of plethora factors released by senescent cells, called associated secretory phenotype (SASP). We have previously shown that in proliferating nuclear lncRNA MIR31HG inhibits p16/CDKN2A expression interaction with polycomb repressor complexes and dur...