This study examined the influence of phonological working memory on sentence comprehension in children with specific language impairment (SLI). Fourteen children with SLI and 13 with normal language (NL) participated in two tasks. In the first, a nonsense word repetition task (index of phonological working memory), subjects repeated nonsense words varying in length from one syllable to four. In...

Two rice (Oryza sativa) waxy mutations of the Japonica background were shown to contain approximately 20% of the fully spliced mRNA relative to the wild type. Sequencing analysis of the entire waxy genes of the two mutants revealed the presence of premature translation termination codons in exon 2 and exon 7. These results indicated that the lower accumulation of fully spliced RNA in the mutant...

Central to a new, or 'resolute', reading of Wittgenstein's Tractatus LogicoPhilosophicus is the idea that Wittgenstein held there an 'austere' view of nonsense: the view, that is, that nonsense is only ever a matter of our failure to give words a meaning, and so that there are no logically distinct kinds of nonsense. Resolute readers tend not only to ascribe such a view to Wittgenstein, but als...

In many organisms nonsense mutations decrease the level of mRNA. In the case of mammalian cells, it is still controversial whether translation is required for this nonsense-mediated RNA decrease (NMD). Although previous analyzes have shown that conditions that impede translation termination at nonsense codons also prevent NMD, the residual level of termination was unknown in these experiments. ...

Premature translation termination codons resulting from nonsense or frameshift mutations are common causes of genetic disorders. Complications arising from the synthesis of C-terminally truncated polypeptides can be avoided by 'nonsense-mediated decay' of the mutant mRNAs. Premature termination codons in the beta-globin mRNA cause the common recessive form of beta-thalassemia when the affected ...

Nonsense mutations underlie about 10% of rare genetic disease cases. They introduce a premature termination codon (PTC) and prevent the formation of full-length protein. Pharmaceutical gentamicin, a mixture of several related aminoglycosides, is a frequently used antibiotic in humans that can induce PTC readthrough and suppress nonsense mutations at high concentrations. However, testing of gent...