By using the Coons indirect immunofluorescence technique, enkephalin-like immunoreactivity with a granular localization was observed in human adrenal medullary gland cells and pheochromocytomas. In two of the tumors and in a few adrenal gland cells, a somatostatin-like peptide could also be identified. Catecholamine cell types were visualized on adjacent sections with antisera to the synthesizi...

Venlafaxine is a selective serotonin, noradrenalin, and dopamine reuptake inhibitor. Although side effects are rare, venlafaxine has very occasionally been associated with hypersensitivity pneumonitis. We report the case of a 61-year-old woman diagnosed with depressive disorder and treated with venlafaxine (Dobupal) at a dose of 150 mg/d for 18 months. When depression worsened, the dose was inc...

Okada, A., Yamashita, T., Nagano, C., Ikeda, T., Yachi, A., and Shibata, S. (1971). Brit. J. industr. Med., 28, 353-357. Studies on the diagnosis and pathogenesis of Raynaud's phenomenon of occupational origin. Experiments were designed to investigate tests for the diagnosis of Raynaud's phenomenon of occupational origin between attacks and to investigate the pathogenesis, particularly with ref...

The pathological manifestations of fatal cases of human hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) are characterized by inflammatory damage to the central nervous system (CNS). Here, the dynamic distribution of EV71 in the CNS and the subsequent pathological characteristics within different regions of neonatal rhesus macaque brain tissue were studied using a chimeric E...

Submit Manuscript | http://medcraveonline.com Abbreviations: 5-HT: 5 Hydroxy Triptamine; AD: Alzheimer Disease; Aβ: Amyloid-β; Aβ 1-42 and Aβ 1-40: Shorter peptides of Aβ released during pathogenesis; ApoE: Apolipoprotein E; CI: Cognitive Impairment; CMV: Cytomegalovirus; CRP: C Reactive Protein; CSF: Cerebrospinal Fluid; CSN: Central Nervous System; DA: Dopamine; EBV Epstein-Barr Virus; GF: Ge...

The aim of the present study was to investigate if there is an altered expression of alpha-adrenoceptors during organ culture of rat mesenteric artery segments by using a sensitive pharmacological method and molecular biological techniques. Noradrenalin (NA) induced contraction via alpha1-adrenoceptors. The contraction and alpha1A-adrenoceptor mRNA levels were elevated during organ culture. Tra...

Serotonin is a fundamental neuromodulator in both vertebrate and invertebrate nervous systems, with a suspected role in many human mental disorders. Yet, because of the complexity of serotonergic function, researchers have been unable to agree on a general theory. One function suggested for serotonin systems is the avoidance of threat. We propose and review evidence for an alternative hypothesi...

trials” Some clinics in Australia and overseas have begun offering a course of ketamine treatments to patients with depression. However, this practice is premature, given that the efficacy and safety of this treatment approach has yet to be tested in controlled trials. Further, whether such a treatment approach leads to lasting response — that is, clinically meaningful effects — is as yet unkno...

Noradrenalin modulates prefrontal function, such as working memory (WM), and is associated with enhanced distractibility, and enhanced memory for emotional events and stimuli. The beta-blocker propranolol has been shown to reduce memory for emotional stimuli. Herein we describe investigations aimed at assessing whether the administration of propranolol would reduce the interference by emotional...