نتایج جستجو برای: npm1 mutation

تعداد نتایج: 292091  

2012
Cheng-Der Liu Ya-Lin Chen Yi-Li Min Bo Zhao Chi-Ping Cheng Myung-Soo Kang Shu-Jun Chiu Elliott Kieff Chih-Wen Peng

Epstein-Barr Virus (EBV) is an oncogenic γ-herpesvirus that capably establishes both latent and lytic modes of infection in host cells and causes malignant diseases in humans. Nuclear antigen 2 (EBNA2)-mediated transcription of both cellular and viral genes is essential for the establishment and maintenance of the EBV latency program in B lymphocytes. Here, we employed a protein affinity pull-d...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2011
W-C Chou H-A Hou C-Y Liu C-Y Chen L-I Lin Y-N Huang Y-C Chao C-A Hsu C-F Huang H-F Tien

BACKGROUND The level of minimal residual disease (MRD) in acute myeloid leukemia (AML) at early time points (TPs) may be an important prognostic factor. Although internal tandem duplication of FLT3 (FLT3-ITD) as an MRD marker has been questioned for its instability based on semi-quantitative methods, we hypothesized that FLT3-ITD dynamics measured by sensitive quantitative real-time PCR at earl...

2015
Sang Hyuk Park Hyun Ji Lee In-Suk Kim Jeong-Eun Kang Eun Yup Lee Hyeoung-Joon Kim Yeo-Kyeoung Kim Jong-Ho Won Soo Mee Bang Hawk Kim Moo-Kon Song Joo Seop Chung Ho-Jin Shin

BACKGROUND To identify potential molecular prognostic markers in core binding factor (CBF) AML, we analyzed incidences and prognostic impacts of mutations in c-KIT, WT1, CEBPA, CBL, and a number of epigenetic genes in CBF AML. METHODS Seventy one and 21 AML patients with t(8;21) and inv(16) were enrolled in this study, respectively. NPM1, CEBPA, c-KIT, IDH1/2, DNMT3A, EZH2, WT1, and CBL mutat...

Journal: :Blood 2011
Ramesh Balusu Warren Fiskus Rekha Rao Daniel G Chong Srilatha Nalluri Uma Mudunuru Hongwei Ma Lei Chen Sreedhar Venkannagari Kyungsoo Ha Sunil Abhyankar Casey Williams Joseph McGuirk Hanna Jean Khoury Celalettin Ustun Kapil N Bhalla

Nucleophosmin 1 (NPM1) is an oligomeric, nucleolar phosphoprotein that functions as a molecular chaperone for both proteins and nucleic acids. NPM1 is mutated in approximately one-third of patients with AML. The mutant NPM1c+ contains a 4-base insert that results in extra C-terminal residues encoding a nuclear export signal, which causes NPM1c+ to be localized in the cytoplasm. Here, we determi...

Journal: :Blood 2021

Abstract Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in approximately one-third adult acute myeloid leukemia (AML). NPM1-mutated AML exhibits unique molecular, pathological, and clinical features, which led to its recognition as distinct entity 2017 World Health Organization (WHO) classification neoplasms. Although WHO criteria diagnosis a...

2016
Kai Yang Ming Wang Yuzheng Zhao Xuxu Sun Yi Yang Xie Li Aiwu Zhou Huilin Chu Hu Zhou Jianrong Xu Mian Wu Jie Yang Jing Yi

The nucleolus has been recently described as a stress sensor. The nucleoplasmic translocation of nucleolar protein nucleophosmin (NPM1) is a hallmark of nucleolar stress; however, the causes of this translocation and its connection to p53 activation are unclear. Using single live-cell imaging and the redox biosensors, we demonstrate that nucleolar oxidation is a general response to various cell...

Journal: :Blood 2011
Vera Grossmann Enrico Tiacci Antony B Holmes Alexander Kohlmann Maria Paola Martelli Wolfgang Kern Ariele Spanhol-Rosseto Hans-Ulrich Klein Martin Dugas Sonja Schindela Vladimir Trifonov Susanne Schnittger Claudia Haferlach Renato Bassan Victoria A Wells Orietta Spinelli Joseph Chan Roberta Rossi Stefano Baldoni Luca De Carolis Katharina Goetze Hubert Serve Rudolf Peceny Karl-Anton Kreuzer Daniel Oruzio Giorgina Specchia Francesco Di Raimondo Francesco Fabbiano Marco Sborgia Arcangelo Liso Laurent Farinelli Alessandro Rambaldi Laura Pasqualucci Raul Rabadan Torsten Haferlach Brunangelo Falini

Among acute myeloid leukemia (AML) patients with a normal karyotype (CN-AML), NPM1 and CEBPA mutations define World Health Organization 2008 provisional entities accounting for approximately 60% of patients, but the remaining 40% are molecularly poorly characterized. Using whole-exome sequencing of one CN-AML patient lacking mutations in NPM1, CEBPA, FLT3-ITD, IDH1, and MLL-PTD, we newly identi...

Journal: :EMBO reports 2008
Markus Haindl Thomas Harasim Dirk Eick Stefan Muller

The ubiquitin-like SUMO system functions by a cyclic process of modification and demodification, and recent data suggest that the nucleolus is a site of sumoylation-desumoylation cycles. For example, the tumour suppressor ARF stimulates sumoylation of nucleolar proteins. Here, we show that the nucleolar SUMO-specific protease SENP3 is associated with nucleophosmin (NPM1), a crucial factor in ri...

2017
Jianhuang Lin Mitsuyasu Kato Kyosuke Nagata Mitsuru Okuwaki

NPM1/nucleophosmin is frequently overexpressed in various tumors, although the oncogenic role of NPM1 remains unclear. Here we revealed the link between NPM1 and nuclear factor-κB (NF-κB), a master regulator of inflammation. We found that NPM1 knockdown decreased NF-κB-mediated transcription of selected target genes by decreasing the recruitment of NF-κB p65 to the gene promoters. NPM1 is direc...

2010
Hiroyuki Nishikawa Wenwen Wu Yukinori Okada Ashok R. Venkitaraman Tomohiko Ohta

Downlo tein accumulation at DNA double-strand breaks (DSB) is essential for genome stability; however, the nisms governing these events are not fully understood. Here, we report a new role for the nucleophosrotein NPM1 in these mechanisms. Thr199-phosphorylated NPM1 (pT199-NPM1) is recruited to nuclear amage foci induced by ionizing radiation (IR). Foci formation is impaired by depletion of the...

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