نتایج جستجو برای: nramp1

تعداد نتایج: 334  

Journal: :Journal of immunology 2007
Karine Turcotte Susan Gauthier Danielle Malo Mifong Tam Mary M Stevenson Philippe Gros

The chronic myeloid leukemia syndrome of the BXH-2 mouse strain (Mus musculus) is caused by a recessive mutation (R294C) in the transcriptional regulator Icsbp1/IRF-8. In trans activation assays using an IL-12p40 gene reporter construct introduced in RAW 264.7 mouse macrophages, we show that the Icsbp1(C294) isoform behaves as a partial loss-of-function. The Icsbp1(C294) hypomorph allele appear...

2002
J F Telfer J H Brock

Objective: To gain a better understanding of how iron accumulates in human rheumatoid synovium. Methods: The distribution of ferritin, transferrin receptor, and non-specific resistance associated macrophage proteins 1 and 2 (Nramp1 and Nramp2) in the human rheumatoid synovium was investigated by immunocytochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). Results: Both heav...

Journal: :Antimicrobial agents and chemotherapy 2008
Ofir Menashe Elena Kaganskaya Timor Baasov Sima Yaron

The high antibacterial activity and selectivity of aminoglycosides and their low activity against intracellular bacteria associated with eukaryotic cells make them the antibiotics of choice for the elimination of extracellular bacteria during intracellular studies. Given the evidence that aminoglycosides can penetrate the eukaryotic cell membrane, the goal of this study was to examine the influ...

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