Mutations in several mitochondrial DNA and nuclear genes involved in mitochondrial protein synthesis have recently been reported in combined respiratory chain deficiency, indicating a generalized defect in mitochondrial translation. However, the number of patients with pathogenic mutations is small, implying that nuclear defects of mitochondrial translation are either underdiagnosed or intraute...

Corresponding Authors: Ping Chen, e-mail: [email protected]; Tao Hu, e-mail: [email protected] Source of support: This work was supported by the National Natural Science Foundation of China (Grant No. 81001102, 81101894, 81672421), the Natural Science Foundation of Henan Province (Grant No. 162300410302), the Outstanding Young Talent Research Fund of Zhengzhou University (Grant No. 5199...

Mitochondrial number and function are altered in response to external stimuli in eukaryotes. While several transcription/replication factors directly regulate mitochondrial genes, the coordination of these factors into a program responsive to the environment is not understood. We show here that PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and res...

Compensation for respiratory motion has been identified as a crucial factor in achieving high resolution Nuclear Medicine (NM) imaging. Many motion correction approaches have been studied and they are seen to have advantages over simpler approaches such as respiratory gating. However, all motion correction approaches rely on an assumption or estimation of respiratory motion. This paper builds u...