Portfolio optimization inputs differ widely from their subsequent out-of-sample (OOS) values. As a result, optimized portfolios have 2 to 28 times more risk OOS than their ex-ante estimates suggest. I propose a simple solution to this problem: let the data speak for itself and pick, in real time, the correction that most reduces past OOS errors. The resulting optimized portfolios consistently o...

Background: Curcuma longa generally known as turmeric includes curcuminoids and sesquiterpenoids as components, which are known to have antioxidative, anticarcinogenic, and anti-inflammatory activities. Iron, magnetite, and hematite as a micronutrient play an important role in physiological and chemical processes. Chitosan is a natural polymer derived from chitin and is recognized as versatile ...

The amide bond in the title compound {systematic name: 3-[(2,4,6-trimethyl-phen-yl)amino-carbon-yl]propionic acid}, C(13)H(17)NO(3), has a trans conformation. In the crystal, two mol-ecules form a centrosymmetric dimer connected by pairs of O-H⋯O hydrogen bonds. Inter-molecular N-H⋯O hydrogen bonds link the dimers into a three dimensional network.

OBJECTIVE To obtain information on practitioner experience in the use of the Genesys HydroThermAblator (HTA) System under normal clinical conditions through documentation of the system's acute safety features, in terms of burn rates, and its technical reliability. STUDY DESIGN This was a prospective, observational, multicenter, postmarket interventional clinical trial with outcome measures of...

We recently reported that electret, which was prepared by a corona charging system with polypropylene film, could enhance the transdermal delivery of several drugs of low molecular weight. The aim of this study was to investigate whether electret could enhance the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles (TMC NPs) prepared by an ionic gelation method. A series...

OBJECTIVE To assess the clinical relevance and newsworthiness of the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme funded reports. STUDY DESIGN Retrospective cohort study. SETTING The cohort included 311 NIHR HTA Programme funded reports publishing in HTA in the period 1 January 2007-31 December 2012. The McMaster Online Rating of Evidence (MO...

A conjugate from the YIGSR peptide and chitosan has been prepared on the basis of a regioselective modification strategy of chitosan, and its antimetastatic activity has been assayed. Chitosan was converted to its organosoluble derivative, 6-O-trityl-chitosan, in 3 steps, and then coupled with the peptide portion containing a spacer amino acid, Ac-Tyr-Ile-Gly-Ser-Arg-beta Ala-OH [beta Ala; beta...

In the present work, we focus on the free volume evaluations from different points of view, including the aspect of probe sizes, temperature, and cavity threshold. The free volume structure is analyzed on structures of poly(vinyl methylether) prepared by fully atomistic molecular dynamics. At first, the temperature behavior of an overall free volume and a free volume separated into individual c...