children with malignant disease receiving phenothiazines for nausea, cerebral metastases or irradiation effects may be considered (Cottom and Newman, 1966). The acute toxic reactions to phenothiazines are self-limiting, the symptoms subsiding in 24 to 48 hours. They can, however, be rapidly and specifically relieved by the anticholinergic/antihistamine group of drugs commonly used for the treat...