In this study, we integrated our understanding of biochemistry, physiology, and metabolism of three commonly used organic solvents with computer simulation to present a new approach that we call "in silico" toxicology. Thus, we developed an interactive physiologically based pharmacokinetic (PBPK) model to predict the individual kinetics of trichloroethylene (TCE), perchloroethylene (PERC), and ...

doi:10.1093/occmed/kqv169 5. Bonneterre V, Faisandier l, Bicout D et al.; RNV3p. programmed health surveillance and detection of emerging diseases in occupational health: contribution of the French national occupational disease surveillance and prevention network (RNV3p). Occup Environ Med 2010;67:178–186. 6. panizza C, Bai E, Oddone E et al. lung cancer risk in the electroplating industry in l...

The induction by chemicals of allergic sensitization and allergic disease is an important and challenging branch of toxicology. Skin sensitization resulting in allergic contact dermatitis represents the most common manifestation of immunotoxicity in humans, and many hundreds of chemicals have been implicated as skin sensitizers. There are far fewer chemicals that have been shown to cause sensit...

In the last issue of Asia Pacific Journal of Medical Toxicology (APJMT), editor-in-chief, Dr. Reza Afshari focused on an important contemporary issue of empowering toxicology in the Asia pacific region (1). The topic drew our attention and we would like to share the situation of Bangladesh in light of this editorial. Dr. Afshari correctly emphasized on forming national societies of medical toxi...

Since 2002, a workshop entitled “Asthma in animal models” has been held once a year in Hannover, Germany. It is organized by the Fraunhofer Institute of Toxicology and Experimental Medicine in collaboration with the collaborative research centre “Sonderforschungsbereich” 587, “Immune reactions of the lung in infection and allergy” (Hannover Medical School). The aim of these meetings is an inten...

This issue is concerned with the provision of occupational health services and the people who provide it; in other words, the effectiveness of occupational health workers and the effects of that work on their health. Continuing the theme, this issue also publishes a number of original papers which examine the effects of health care work on health care workers. Whilst there are undoubtedly chang...

Legal and medical practitioners need to remember that, with respect to drug analysis, there are two distinct disciplines in analytical toxicology concerned with human biological matrices, namely clinical and forensic toxicology. Both fields use similar analytical techniques designed to detect and quantify drugs, chemicals and poisons in fluids or tissues. In clinical toxicology, analytical resu...

The International Conference on Environmental Cadmium was held June 7-9, 1978 on the NIH Campus in Bethesda, Maryland, to summarize the current level of scientific knowledge about cadmium as an environmental agent and to identify needed areas of research. The meeting was sponsored by the National Institute of Environmental Health Sciences and the Department of Environmental Hygiene, Karolinska ...