An eye is the most precious and easily accessible organ of the body. It possesses easy route to local drug delivery and is a way to non-invasive clinical treatment of ocular diseases. Ocular delivery in spite of possessing various advantages has the limitation of poor bioavailability and low permeability across the cornea thus, limiting the efficacy of drugs. Therefore, various carrier systems ...

Efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions, ointment and other drug delivery devices like inserts, implants, gelling systems, etc. These conventional and novel dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomical...

Objective(s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF.Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...

Ocular Conjunctivitis is one of the main causes of red eye syndrome. The present work focuses on the treatment of ocular conjunctivitis by using combined mechanisms: 1.Formulation of ocular inserts to provide prolonged and sustained release system of the drug. 2.Use of therapeutic agent, as ciprofloxacin hydrochloride in combination with the polymers used. The selected polymers were methylcellu...

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...