background & objective: the current approaches to reduce the risk of colorectal carcinoma are through the detection and removal of the precursor lesion” adenomatous polyps”. the study was conducted to evaluate the immunohistochemical expression of p53 and bcl2 in colorectal adenomas and carcinomas. patients and methods: a total of 86 cases, 33 colorectal adenomas, 33 colorectal adenocarcin...

Purpose: To investigate the expression of miR-125b and vitamin D receptor (VDR) in renal cell carcinoma (RCC) assess biological function RCC. Methods: We used quantitative real-time polymerase chain reaction (RT-PCR) to detect nucleic acids western blotting analyze protein abundance RCC lines. MiR-125b mimic inhibitor were employed behavior The relationship between miR-125 VDR was verified usin...

background neuroblastoma is the most common extracranial malignant solid tumor in children under 5 years, and it is characterized by wide clinical and biological heterogeneity. n-myc oncogene amplification is considered to be one of the most important prognostic factors used to evaluate survival in these patients. objectives the aim of our study was to determine amplification of the n-myc oncog...

Qing’E pills are a classical formula in traditional Chinese medicine that has the effect of tonifying kidneys and strengthening bones, first appearing tonic formulae prescriptions peaceful benevolent dispensary (10th century CE). To preliminarily elucidate potential mechanisms treatment postmenopausal osteoporosis based on network pharmacology. The principal components corresponding protein tar...

Esophageal cancer is a common among people in the world. The molecular mechanism of complement C1q tumor necrosis factor related protein 6 esophageal still unclear. This article aimed to clarify role cancer. expression tissues was detected using quantitative real-time polymerase chain reaction and Western blot. Furthermore, short hairpin ribonucleic acid used knockdown cell lines. 3-(4,5-dimeth...

Netrin-G1 (NTNG1) is a glycosyl-phosphatidylinositol-affixed synaptic adhesion molecule that participates in carcinoma developments. However, its underlying mechanism regulating prostate cancer (PCa) uncertain. NTNG1 mRNA and protein expressions tissue samples cells were demonstrated to be promoted using RT-qPCR western blot. Thereafter, CCK-8, overexpression accelerated PCa cell viability whil...

Melanoma is a highly aggressive kind of cancer with very poor prognosis. v-Raf murine sarcoma viral oncogene homolog B1 inhibitor vemurafenib has indeed harvested substantial clinical benefits. Nevertheless, its drug resistance also hampered scientists’ efforts towards successful melanoma treatment. In this study, we used data derived from the gene expression omnibus database to analyze effect ...

Chromosomal translocation is one mechanism by which cellular oncogenes may be activated during tumorigenesis. The translocation of the abl oncogene to the Philadelphia chromosome in chronic myelogenous leukemia (CML) results in a new RNA transcript that fuses sequence from chromosome 22 to sequence from the abl oncogene. This RNA presumably codes for a new abl-related protein product found in C...

The KRAS gene (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is involved in the regulation of cell division as a result of its ability to relay external signals to the cell nucleus. Activating mutations in the KRAS gene impair the ability of the KRAS protein to switch between active and inactive states, leadi...

objective: breast cancer is the most common cause of cancer-related deaths in women both worldwide and in malaysia. azadirachta indica (a. juss), commonly known as neem, is one of the most versatile medicinal plants that has gained worldwide prominence due to its medicinal properties. however, the anticancer effect of ethanolic neem leaf extract against breast cancer has not been documented. th...