Recent studies suggest that abnormal melatonin functions may be implicated in the pathophysiology of schizophrenia. Since there is evidence that the presence of pineal calcification (PC) may relate, among other factors, to disturbances in melatonin secretion, I investigated in 23 chronic institutionalized schizophrenic patients the relationship of PC size on CT scan to the mode of onset of schi...

The phenomenological presentation of late-onset schizophrenia is a topic of considerable debate. This study aims to look at the clinical presentation of late-onset schizophrenia. Charts of all subjects who received a diagnosis of schizophrenia between January 1990 and December 1993 with age of onset being 45 or more were systematically analysed using the OPCRIT checklist. Of the 89 subjects cho...

Background: Few studies investigated brain abnormalities in early onset schizophrenia. Objective: To assess computed tomography (CT) abnormalities in patients with childhood or adolescence onset schizophrenia. Method: CT scans of patients with childhood (6 to 11 years old) (N=6) or adolescence (12-17 years old) (N=9) schizophrenia were compared to normal controls. Patients were diagnosed based ...

BACKGROUND Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability. A twin approach can be valuable, because it allows for the investigation of specific illness markers in individuals with a shared genetic background. METHODS We linked nationwide registers to identify a cohort of twin pairs ...

OBJECTIVE To review the literature about functional psychosis in children and adolescents, allowing pediatricians to recognize the pathology in their daily work routine. SOURCES OF DATA Classical textbooks of child and adolescent psychiatry; search of MEDLINE and Lilacs databases (1993 to 2003). Computerized search methods were combined with manual search of the literature. SUMMARY OF THE F...