Candida albicans strains that are homozygous at the mating type locus (MTLa or MTLalpha) can spontaneously switch at a low frequency from the normal yeast cell morphology (white) to an elongated cell type (opaque), which is the mating-competent form of the fungus. The ability to switch reversibly between these two cell types also contributes to the pathogenicity of C. albicans, as white and opa...

The human pathogen Candida albicans can assume either of two distinct cell types, designated "white" and "opaque." Each cell type is maintained for many generations; switching between them is rare and stochastic, and occurs without any known changes in the nucleotide sequence of the genome. The two cell types differ dramatically in cell shape, colony appearance, mating competence, and virulence...

Modes of sexual reproduction in eukaryotic organisms are extremely diverse. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally- and morphologically-differentiated white and opaque cells show a coordinated behavior during mating. Although white cells are mating...

The relationship between the configuration of the mating type locus (MTL) and white-opaque switching in Candida albicans has been examined. Seven genetically unrelated clinical isolates selected for their capacity to undergo the white-opaque transition all proved to be homozygous at the MTL locus, either MTLa or MTLalpha. In an analysis of the allelism of 220 clinical isolates representing the ...

tIHE Council begs to present the seventy-second anntual report of the Society. Tlhe roll of the Society now stands as follows T'his 1Year Last Year Honorary Fellows 7 9 Life Fellows 13 11 Life MNem-nbers (under o0l regtulationis) 2 2 Fellowxs 274 243 Members 39 During the sessioni the Societv has lost by (leath Sir WN'illiam \Vhitla, M.A., MI.D., LL.D., Honorary Fellow, Presi(lent 1886-7, 1901-...

Opaque scintillators are designed to have a short scattering length such that scintillation photons probabilistically confined small region of space about their origin. The benefit this feature is information on the interaction event topology can be recorded with greater fidelity than in traditional highly transparent media sensors at large distances from light production region. scintillator d...