H1 receptor histaminergic antagonist, chlorpheniramine (CPA) participates in cognitive performance in various animal models. However, little is known regarding the effects of CPA microinjection into the amygdala on emotional behavior. The purpose of this study was to investigate whether CPA microinjection into the amygdala has the same effect on two models, one anxiety- and the other fear-media...

Behavioral studies have suggested an involvement of the glutamate pathway in the mechanism of action of anxiolytic drugs, including the NMDA receptor complex. It was shown that magnesium, an NMDA receptor inhibitor, exhibited anxiolytic-like activity in the elevated plus-maze test in mice. The purpose of the present study was to examine interaction between magnesium and benzodiazepine/GABA(A) r...

Previous studies have demonstrated that repeated submission of rats to mild hypobaric hypoxia reduces the persistent behavioral and hormonal depressive symptoms induced by exposure to footshock in the learned helplessness paradigm. The aim of this study was to determine whether hypoxic preconditioning of mice can also induce antidepressant- and anxiolytic-like effects that are detectable with t...

The present study was undertaken to evaluate anxiolytic activity of alcoholic flowers extract of Tabernaemontana divaricata (Linn) R.Br. (ALETD) by using mice. This plant contains carbohydrates, steroids, tannins, triterpenes, flavonoids, proteins, amino acids and glycosides. Anxiolytic effect of ALETD (100, 200 and 400 mg/kg) was studied and diazepam used as a standard drug by using following ...

Xiaoyaosan (XYS) decoction has been widely used as a traditional medicine for treating stress and depression-related disorders in China for thousands of years. Aim of the Study. To observe the potential mechanism of XYS decoction's antidepressant-like effect in α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors related to synaptic plasticity in the hippocampus rats induced b...

In recently, many studies tried that fine medicinal plant that may be useful in treatment of psychological diseases. Coriandrum sativum (CS) overgrows in the different parts of Iran. In this study we investigated the effects of hydro-alcoholic extract of Coriandrum sativum on anxiety reaction in Mice. In this study, fourty male mice (25-30 gr) in elevated plus maze model were used. Different do...

Many abused substances have been found to possess anxiogenic-like or/and anxiolytic-like properties. Discrepancies about the effects of MDMA, one of the most popular recreational drugs in recent years, on anxiety have been seen in the literature, and almost all of the data in this respect were derived from retrospective studies. The present study was thus designed to examine the drug's actions ...

The present study examined the effects of chewing on stress-induced long-term depression (LTD) and anxiogenic behavior. Experiments were performed in adult male rats under three conditions: restraint stress condition, voluntary chewing condition during stress, and control condition without any treatments except handling. Chewing ameliorated LTD development in the hippocampal CA1 region. It also...

the present study was designed to study the preventive effect of hydroalcoholic extract of ripe pistachio hulls (rph) in the elevated plus maze model of anxiety. one hundred twenty female wistar rats in their estrous cycle were divided into 15 groups of 8 each and received various concentrations of hydroalcoholic extract of rph except the control groups. elevated plus maze was used to measure t...