Ocular drug delivery is limited both by patient acceptability and by the limited time that the dosage form is retained within the precorneal region. The timely gelation and retention of in situ-gelling ophthalmic formulations would be fundamental to improve the efficacy of drugs. The aim of this investigation was to develop ocular drug delivery system with simplicity in installation for patient...

Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development of in vitro representations of organs for drug toxicity assessment. Due to the ever-increasing interest in ocular drug delivery as a route for administration as well as...

This report describes the efficacy of a novel mucoadhesive polymer, the tamarind seed polysaccharide, as a delivery system for the ocular administration of hydrophilic and hydrophobic antibiotics. Healthy rabbits were subjected to repeated ocular instillations with either conventional gentamicin or ofloxacin or these agents viscosified with the tamarind seed polysaccharide. Administration of vi...

purpose: to report a case of proteus syndrome with new ophthalmic findings not reported elsewhere. patient and findings: the patient is an 18-year-old girl with red lesions on hand and foot from birth and disproportionate growth of right upper and lower limbs from the first year of life. on examination, the patient has enlargement of the right upper and lower limb, macrodactyly, vascular malfor...

In recent years, ophthalmic drug delivery has been recognised as having some of the most significantly unmet packaging and delivery needs of any injectable drug market segment. Ocular injections often require very small, precise dose volumes to be administered in a smooth, controlled manner to a precise location in the eye without the introduction of air bubbles or foreign particulate matter su...

The human eye and tear provide essential physiological information for the detection of ocular dysfunctions therapy monitoring. measurements biomarkers in composition are critical disease diagnosis early interventions. Hence, significant efforts dedicated to development functional contact lenses that can quantify analytes condition. combination microfluidics lens technologies offer real-time mo...

Ocular drug delivery has been a major challenge for scientists due to its unique anatomy and physiology which contains various types of barriers such as different layers of cornea, sclera and retina including blood aqueous and blood–retinal barriers, choroidal and conjunctival blood flow etc. These barriers cause a significant challenge for delivery of a drug alone or in a dosage form, especial...

VISION 2020: The Right to Sight has provided a vision and a common goal for eye care programmes. It has provided the paradigm shift, or change in the way of thinking, from individual patient care to population care, a shift from each person doing a job or task, to a group working to eliminate avoidable blindness. Such a common goal needs a team approach. The VISION 2020 approach proposes that a...

Age-related ocular diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and glaucoma, result in life-long functional deficits and enormous global health care costs. As the worldwide population ages, vision loss has become a major concern for both economic and human health reasons. Due to recent research into biomaterials and nanotechnology major advances have been gai...