Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and beta-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and beta-endorphin was significa...

‎ introduction: controversial results have been reported about the effect of morphine and stress on learning and spatial memory in rodents. there are very few studies about the effects of ultra low doses of morphine on memory. in this study, effects of acute administration of low and usual doses of morphine on memory formation and retention in the presence and absence of repeated stress were in...

BACKGROUND This study was designed to assess whether nonalcoholic offspring from families with a high density of alcohol-dependent individuals have altered endogenous central nervous system opioid activity. Naloxone hydrochloride stimulates plasma cortisol by blocking opioidergic input on the corticotropin-releasing factor neuron, thereby providing a noninvasive method for measuring hypothalami...

BACKGROUND Ischemic preconditioning and postconditioning are the novel strategies of attaining cardioprotection against ischemia/reperfusion (I/R) injury. Previous studies suggested the role of opioid pathway, however the class of opioid receptors responsible for this effect in humans remains unknown. The aim of the study was to assess the influence of opioids on simulated I/R injury outcomes i...

‎ Introduction: Controversial results have been reported about the effect of morphine and stress on learning and spatial memory in rodents. There are very few studies about the effects of ultra low doses of morphine on memory. In this study, effects of acute administration of low and usual doses of morphine on memory formation and retention in the presence and absence of repeated stress w...

The participation of opioids in the antinociceptive effect of electroacupuncture was evaluated in terms of nociception produced by thermal stimuli applied to the face of male Wistar rats, weighing 180-230 g. Electrical stimulation (bipolar and asymmetric square wave with 0.5 mA intensity for 20 min) of acupoint St36, located in the anterior tibial muscle 10 mm distal to the knee joint, induced ...