A 66-year-old man was admitted with visual impairment, functional disability, and worsening glycemic control. On admission, he had optic atrophy without diabetic retinopathy in both eyes, sensory impairment of the lower extremities, ataxia, and cognitive impairment. As both serum and cerebrospinal fluid tested positive for syphilis, he was diagnosed with neurosyphilis and treated with antibioti...

Nicte I. Mejia MD* Soojin Park, MD* MingMing Ning, MD Ferdinando S. Buonanno, MD The syndrome of ocular apraxia, simultagnosia, and optic ataxia originally described by Balint in 1909 is classically associated with bilateral parieto-occipital lesions, but can occur with other combinations of bihemispheric lesions.1,2 This syndrome reflects multiple etiologies, most commonly vascular disease, bu...

BACKGROUND Posterior cortical atrophy is a clinical syndrome that is characterized by the progressive loss of visuospatial integration and is associated with neurodegenerative conditions. CASE REPORT We describe a 60-year-old female with simultanagnosia, oculomotor apraxia, and optic ataxia for which she received an initial clinical diagnosis of posterior cortical atrophy. Three years later, ...

Definition Specific impairment of the visual control of limb movements observed in patients with lesion of the posterior parietal cortex. This deficit is expressed as errors both in final limb position in reaching/pointing tasks and in the shaping of hand aperture in grasping tasks. These deficits are exacerbated when the movements are programmed and executed under peripheral vision by asking t...

Biotinidase deficiency is a disorder inherited autosomal recessively showing evidence of hearing loss and optic atrophy in addition to seizures, hypotonia, and ataxia. In the present study, a 2-year-old boy with Biotinidase deficiency is presented in which clinical symptoms have been reported with auditory neuropathy/auditory dyssynchrony (AN/AD). In this case, transient-evoked otoacoustic emis...

Friedreich's ataxia, a hereditary disorder of the nervous system, is characterized by the onset of ataxia of gait, weakness and clumsiness of the limbs, and dysarthria of speech in young patients of either sex. Loss of tendon reflexes, usually combined with extensor plantar responses and impairment of vibration and joint sense, is often found. Nystagmus is common. Complications include mental s...

When vision is removed, limb position has been shown to progressively drift during repetitive arm movements. The posterior parietal cortex (PPC) known be involved in the processing of multisensory information, formation internal hand estimate, and online motor control. Here, we compared between healthy controls 2 patients with PPC damage gain insight into mechanisms underlying movement investig...