The direct fluorescent antibody technique of Coons was used to study Von Szily's classical experiment on herpetic uveitis in ivhich inoculation of herpes virus into one eye of a rabbit resulted in the development of uveitis 10 to 14 days later in the opposite uninoculated eye. With the fluorescent antibody technique the virus could be demonstrated in the cells of the iris, ciliary body, corneal...

Introduction There are numerous anatomical details in the brain that are undetectable at image resolutions typically used in diffusion tensor imaging (DTI), being 8mm voxels, due to partial volume effects with surrounding tissue. In addition, the sequence used in the majority of DTI studies, single-shot EPI, is sensitive to magnetic field inhomogeneity near air/tissue interfaces. Because of the...

RATIONALE AND OBJECTIVES The aims of this study was to evaluate, using 3-T diffusion tensor imaging, changes of fractional anisotropy (FA) in the orbital and intracranial part of the optic nerve (ON), the optic chiasm, the lateral geniculate nucleus, and different parts of the optic radiation (OR) in patients with glaucoma compared to controls and to determine whether FA correlates with disease...

At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the transcription factor Zic2 and the guidance receptor EphB1, as shown by two papers ...

We present a case of sarcoidosis in a 14-year-old girl who presented with a short history of visual disturbance. Computed tomography and magnetic resonance imaging (MRI) demonstrated enlargement of the optic chiasm and prechiasmic optic nerves. Post-contrast MRI showed marginal enhancement of the affected areas of the optic pathways. A diagnosis of optic nerve glioma and arachnoid gliomatosis w...

The case material of 42 patients with primary tumors of the optic nerve and chiasm examined at our institution within a 10 year period was reviewed. In each case, the radiologic data and certain clinical information were compiled to determine the role of radiology in the workup of patients with these tumors and to compare the results of various imaging methods. Although different types of infor...

A retinofugal projection to the suprachiasmatic nucleus of the hypothalamus has been described in man by means of a newly developed staining technique (PPD) for tracing degenerated fibers in the human brain. We applied the PPD method to the chiasmal/hypothalamic area of human autopsy brains from patients who had incurred prior optic nerve damage. We followed degenerated fibers from the optic ne...