Several groups have reported the development of dual modality Gamma camera/optical imagers, which are useful tools for investigating biological processes in experimental animals. While previously reported dual modality imaging instrumentation usually employed a separated gamma camera and optical imager, we designed a detector using a position sensitive photomultiplier tube (PSPMT) that is capab...

According to the industrial requirement for optical imaging, particularly in microscopic imaging, resolution improvement is one of the most important issues. In digital microscopic imaging, resolution of an optical system is limited by both optical parameters such as light wavelength and the objective lens numerical aperture and by spatial sampling such as pixel size of charge-coupled device ca...

The hybrid nature of optoacoustic imaging might impose limitations on concurrent placement of optical and ultrasonic detection components, especially in high resolution microscopic applications that require dense arrangements and miniaturization of components. This hinders optimal deployment of the optical excitation and ultrasonic detection paths, leading to reduction of imaging speed and spat...

In this paper, we review three-dimensional (3D) photon counting imaging with axially distributed sensing. Under severely photon-starved conditions, we have proposed various imaging and algorithmic approaches to reconstruct a scene in 3D, which are not possible by using conventional imaging system due to lack of sufficient number of photons. In this paper, we present an overview of optical sensi...

introduction blood pressure (bp) is one of the important vital signs that need to be monitored for personal healthcare. arterial blood pressure is estimated from pulse transit time (ptt). this study uses two pulse sensors to get ptt. the aim of this study was to construct an optical system and to monitor blood pressure continuously and without cuff in people with different ages. materials and m...

According to the industrial requirement for optical imaging, particularly in microscopic imaging, resolution improvement is one of the most important issues. In digital microscopic imaging, resolution of an optical system is limited by both optical parameters such as light wavelength and the objective lens numerical aperture and by spatial sampling such as pixel size of charge-coupled device ca...

We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. T...

A multi-modal optical imaging system for quantitative 3D bioluminescence and functional diffuse imaging is presented, which has no moving parts and uses mirrors to provide multi-view tomographic data for image reconstruction. It is demonstrated that through the use of trans-illuminated spectral near infrared measurements and spectrally constrained tomographic reconstruction, recovered concentra...