Significance: Diffuse optical imaging (DOI) provides in vivo quantification of tissue chromophores such as oxy- and deoxyhemoglobin (HbO2 HHb, respectively). These parameters have been shown to be useful for predicting neoadjuvant treatment response breast cancer patients. However, most DOI devices designed the are nonportable, making frequent longitudinal monitoring during a challenge. Further...

We model the capability of a small (6-optode) time-resolved diffuse optical tomography (DOT) system to infer baseline absorption and reduced scattering coefficients of the tissues of the human head (scalp, skull, and brain). Our heterogeneous three-dimensional diffusion forward model uses tissue geometry from segmented magnetic resonance (MR) data. Handling the inverse problem by use of Bayesia...

Two state-of-the-art profiling floats were equipped with novel optode-based oceanographic oxygen sensors. Both floats were simultaneously deployed in the central Labrador Sea Gyre on Sept. 7, 2003. They drift at a depth of 800 dbar and perform weekly profiles of temperature, salinity and oxygen in the upper 2000 m of the water column. The initial results from the first 6 months of operation are...

The diffusive oxygen uptake (DOU) of sediments inhabited by Chironomus riparius and Tubifex tubifex was investigated using a planar oxygen optode device, and complemented by measurements of bioturbation activity. Additional experiments were performed within contaminated sediments to assess the impact of uranium on these processes. After 72h, the two invertebrate species significantly increased ...

This paper explores a time-resolved functional imaging method based on Monte Carlo model for whole-body functional imaging of small animals. To improve the spatial resolution and quantitative accuracy of the functional map, a Bayesian hierarchical method with a high resolution spatial prior is applied to guide the optical reconstructions. Simulated data using the proposed approach are employed ...

Carbazole is a promising pharmaceutical species. A novel optical sensor for determining doxycycline based on the fluorescence quenching of N-allylcarbazole immobilized on an quartz glass plate surface by covalent bonding has been described. The sensor shows satisfactory virtues in reversibility, repeatability, selectivity and sufficient lifetime resulting from its excellent optode membrane. Its...

The ability of meso-tetra(pentafluorophenyl)porpholactone (T(F)PL) and its Pt(II) complex [meso-tetra(pentafluorophenyl)porpholactonato]Pt(II) (T(F)PLPt) to function as optical high pH sensors is described. Under strongly alkaline or high methoxide conditions, their UV-vis spectra undergo dramatic and reversible red-shifts. The dynamic range for the sensor T(F)PLPt in solution is from pH 11.5 t...

This paper presents a framework for Design For Assembly of hybrid microsystems. Hybrid microsystems are microsystems, mainly semi-conductor based, which offer diverse functionality, and which are realised by integrating elements (die, parts) from different material and technology domains. From macro-domain mechanical products, it is known that the design of these products is of major importance...