Raf Kinase Inhibitory Protein (RKIP) expression has been profiled for a number of unique tissue cancers. However, certain tissues have not been explored, and oral and oropharyngeal cancers stand out as high priority targets, given their relatively high incidence, high morbidity rate, and in many cases, preventable nature. The purpose of this study was to examine changes in RKIP expression and p...

The mandible plays an important role in mastication, speech and facial cosmesis. Apart from direct involvement by oral malignancies, the mandible used to be excised in oral cancers due to its proximity to the tumour, for adequate resection margins and for fear of recurrence as cancer was thought to spread via the periosteal lymphatics. However, with better understanding of spread of oral cancer...

The purpose of the study was to evaluate the expression of IGF-IR in primary tumours and lymph node metastases of oral cancers and the correlation between expression of IGF-IR and some clinicopathological features. Fifty-seven (57) oral cancers were examined by immunohistochemical studies, using the avidin-biotin-peroxidase method. Our study included only oral cancers, classified histopathologi...

Introduction The term “oral cancer” refers to malignant tumors arising in the oral and oropharyngeal mucosa, including those of the tongue and lips. Squamous cancers account for over 90% of oral cancer. Internationally, oral and phamyngeal cancers constitute the sixth commonest site in both sexes combined (1). The highest reported incidences occur in pants of South and Southeast Asia, Brazil, a...

Oral human papillomavirus (HPV) is significantly related to an increasing incidence of certain head and neck cancers. Studies have shown that oral sex is associated with oral HPV. The percentage of oropharyngeal tumors associated with HPV has increased from 16% in 19841989 to 71% in 2000-2004 in the United States. This dramatic increase of HPV-related oral cancers necessitates further investiga...

OBJECTIVE To examine the absolute risks or benefits on cancer associated with oral contraception, using incident data. DESIGN Inception cohort study. SETTING Royal College of General Practitioners' oral contraception study. PARTICIPANTS Directly standardised data from the Royal College of General Practitioners' oral contraception study. MAIN OUTCOME MEASURES Adjusted relative risks betw...