Oral microbes play a critical role in maintaining oral homeostasis. Microbial dysbiosis promotes disease pathogenesis through several mechanisms. Recent studies have revealed that microbial imbalance and sustained inflammation are involved progression. The adverse interaction triggered by host immune response to microorganisms can lead systemic diseases. Here, we reviewed how communicate with h...

evaluation of periodontal status by cpitn among (35-44) – year – old population in khoramabad (2002) dr. f. haghighati* - dr. sh. salehi** - dr. r. valizadeh*** * - associate professor of periodontics dept. - faculty of dentistry – tehran university of medical sciences. **-assistant professor of periodontics dept. - faculty of dentistry – tehran university of medical sciences. ***- dentist. bac...

introduction: multiple myeloma is a neoplasm of monoclonal plasmacells which may cause oral manifestations. we report a 50-year-old man with a mass burned out of a post extraction socket. he had recived an eight month period of chemotherapy and was supposed to be ready for hematopoetic stem cell transplantation. after clinical and histopathological examinations, the mass was diagnosed as a plas...

Probiotics have a role in maintaining oral health through interaction with oral microbiome, thus contributing to healthy microbial equilibrium. The nature and composition of any individual microbiome impacts the general health, being a major contributor to oral health. The emergence of drug resistance and the side effects of available antimicrobials have restricted their use in an array of prop...

BACKGROUND The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status. METHODOLOGY/PRINCIPAL FINDINGS Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. Th...

Understanding of the functional morphology and biology of the oral mucosa has advanced in recent year, particularly in such areas as epithelial-mesenchymal interaction, fibroblast heterogeneity, extracellular matrix, migration factors and growth factors, and the importance of these areas in the development and maintenance of the oral mucosa is increasingly appreciated. This article reviews curr...

lichen planus (lp) is a chronic inflammatory disease of probable immune-based etiology. the pathogenesis of lp is unclear, but apoptotic changes in epidermal (epithelial) cells have been reported. destruction of the basal cell layer is observed and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium. the aim of this study was to evaluate and co...

A wide range of bacterial species are harbored in the oral cavity, with the resulting complex network of interactions between the microbiome and host contributing to physiological as well as pathological conditions at both local and systemic levels. Bacterial communities inhabit the oral cavity as primary niches in a symbiotic manner and form dental biofilm in a stepwise process. However, exces...

BACKGROUND Ventilator-associated pneumonia is a significant cause of morbidity and mortality and may be influenced by oral health. OBJECTIVE To describe the relationship between ventilator-associated pneumonia and oral health status, changes in oral health status during the first 7 days after intubation, and microbial colonization of the oropharynx and trachea. METHODS A total of 66 patient...

The association between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms and oral cancer is not consistent across studies, and data on their interaction with smoking in oral cancer are lacking. The authors systematically searched PubMed and SciVerse Scopus for case-control studies examining the association between null genotypes of theGSTM1 andGST...