background: leukoplakia is a common, potentially premalignant lesion with malignant transformation rate from 1 to 17% with highest transformation rate for the lesions on the floor of the mouth, soft palate and tongue. one of the main etiological factors is consuming areca nut and its commercial preparations which generate high levels of reactive oxygen species during their metabolism. so the ai...

Introduction: Although recent studies show the association of eosinophils with different tumors including oral malignancies, the role of eosinophils in premalignant conditions of the oral cavity is not known precisely. Therefore, this study aimed to determine the number of eosinophils in premalignant and malignant conditions of the oral cavity and its role in progression to malignancy. Materia...

INTRODUCTION Oral lesions have been recognised as prominent features of acquired immune deficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection since the beginning of the epidemic. OBJECTIVE This descriptive study was conducted to study the types of oral lesions among HIV-infected patients in Singapore. MATERIALS AND METHODS Oral examination was done on 81 randomly selec...

OBJECTIVES The Internet provides great opportunities for patient healthcare education, but poses risks that inaccurate, outdated or harmful information will be disseminated. Our objective was determine the quality of the information available on the internet in relation to oral leukoplakia. STUDY DESIGN Sites were identified using 3 search engines (Google, Yahoo and MSN), and the search term ...

Free radical induced lipid peroxidation has been implicated in pathogenesis of several pathological disorders. Lipid peroxidation products malonaldehyde (MDA) was analyzed in 25 patients of leukoplakia, 47 patients of oral submucous fibrosis, 21 patients of candidiasis, 67 patients of dental caries, 62 patients of oral cancer and 50 patients of healthy subject served as a control. Significantly...

OBJECTIVE Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa. STUDY DESIGN Study, by qPCR (quantitative real-time polymerase chain reaction), the expression of COX-2, EGFR and p53 in 24 biopsies of non-dysplastic oral leukoplakia and contra-lateral normal-appearing mucosa. RESULTS COX-2 was up-regulated in leukoplakia (79.2%); whereas EGF...

PURPOSE To test the hypothesis that the retinamide N-(4-hydroxyphenyl)retinamide (fenretinide) would be clinically active potentially via receptor-independent apoptosis and receptor-dependent effects in natural retinoid-resistant oral leukoplakia patients--the first test of this hypothesis in any in vivo setting. EXPERIMENTAL DESIGN A phase II trial of fenretinide (200 mg/d for 3 months) in o...

Oral leukoplakia and erythroleukoplakia are common oral potentially malignant disorders diagnosed in the oral cavity. The specific outcome of these lesions remains to be elucidated, as their malignant transformation rate exhibits great variation. The ability to predict which of those potentially malignant lesions are likely to progress to cancer would be vital to guide their future clinical man...

Background and aims. Many oral squamous cell carcinomas develop from potentially malignant disorders (PMDs)which include a variety of lesions and conditions characterized by an increased risk for malignant transformation. Thisstudy evaluated the quantitative expression of EGFR in normal oral mucosa, oral leukoplakia and oral submucous fibrosis to predict the malignant risk in compliance with th...

Objectives: To assess histopathological characteristics of oral leukoplakia among snuff users and non-users. Material methods: The descriptive cross-sectional study was conducted at different hospitals in Khyber Pakhtunkhwa. consisted 60 cases which 30 were non-users features assessed both groups. SPSS 20 used for the evaluation analysis data. Results: observed mean age 50.3 years. In users, 56...