Burkitt's lymphoma is not an uncommon malignancy in the paediatric population. It is a high-grade non-Hodgkin B-cell lymphoma which may present as endemic, sporadic and human immunodeficiency-associated subtypes. The African, or endemic, variant usually involves the maxilla and other facial bones while head and neck manifestations in sporadic Burkitt's lymphoma are rare. We described a case of ...

Plasmablastic lymphoma is a non-Hodgkin lymphoma characterized by its plasmacytic differentiation and predilection for the oral cavity. It is among the lymphomas most commonly associated with AIDS. This report details a case of a HIV-positive patient with a 1-month history of an exophytic mass in the gingival area of the upper left quadrant. The diagnosis of plasmablastic lymphoma was made base...

Burkitt’s lymphoma (BL) is an uncommon type of Non-Hodgkin lymphoma (NHL). It is a highly aggressive type of B-cell lymphoma and the most common childhood cancer. Treatment for this cancer is still limited. However, a new strategy for refractory tumor, gene therapy is watched with keen interest. One of method for high-efficiency and region-controlled in vitro gene transfer was developed by anti...

Plasmablastic lymphoma (PBL) is a rare B-cell lymphoma occurring mainly in HIV patients. The tumor frequently involves extranodal sites such as the oral cavity, nasal cavity, gastrointestinal tract, skin, and lungs. The neoplastic cells are characterized by a plasmablastic appearance and typical immunophenotype that indicates plasma cell differentiation. Herein, we report a case of intraocular ...

Background: The transcriptional repressor BCL6 is an oncogenic driver often found to be deregulated in lymphoid malignancies. We report the optimisation of our previously reported benzimidazolone molecular glue type degrader CCT369260 CCT373566, a highly potent probe suitable for sustained depletion vivo. Materials and methods: Key discovering CCT373566 were two design approaches: 1) careful, p...

BACKGROUND We describe the unusual case of a 66-year-old woman who presented with a cheek mass that completely abated with oral steroids. CASE REPORT Multiple separate biopsies of the mass were negative or inconclusive. MRI revealed a large mass, yet after a short steroid course, this mass was completely undetectable on clinical examination. A repeat biopsy eventually revealed follicular lymp...

A histological analysis of 3141 cases of oral tumours and tumour-like lesions diagnosed at Kenyatta National Hospital between 1978 and 1992 has been carried out. Squamous cell carcinoma, salivary gland tumours and lymphoid tumours form the majority of lesions. In general, the histological distribution of the oral tumours do not differ significantly from those reported in non African series save...

PURPOSE To report the case of a 53-year-old woman with a 2-year history of episodic upper eyelid swelling and nonspecific complaints, who was diagnosed as having allergic conjunctivitis. METHODS A complete ocular examination, orbital computerized tomographic (CT) scans followed by complete physical and systemic examinations. RESULTS The results of physical and systemic examinations were unr...

The medical records of all patients attending the Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar during 1990 and to 1994 were analysed to determine the frequency of most common cancers. There were 13,359 adults with biopsy proven cancers of these 10,371 belonged to the North West Frontier province (NWFP) and remaining 2,988 were Afghan refugees. In NWFP there were 55% males an...