نتایج جستجو برای: oral protein delivery
تعداد نتایج: 1643793 فیلتر نتایج به سال:
Formulation of biologics for alternative routes of administration: Current problems and perspectives
Introduction: Biologics (biopharmaceuticals) present new promising therapies for many diseases such as cancers, chronical inflammatory and today's biggest challenge - COVID-19. Research: Today, most biologics have been synthetized using modern methods of biotechnology, in particular DNA recombinant technology. Current pharmaceutical forms protein/peptide biopharmaceuticals are intended parenter...
Oral cavity can be used for local drug delivery as in for periodontitis, dental caries or for oral mucosal drug delivery as for alveolar osteitis, analgesia or transmucosal systemic effect as for smoking cessation or delivery of biotechnological products like proteins and peptides. This article gives an overview of basic structure, function, biochemistry, and permeability of the oral cavity. Di...
Induction of specific immunological unresponsiveness by feeding protein antigens is termed oral tolerance and may be a potential therapy for autoimmune diseases. Whereas oral tolerance therapy may be both simple and effective, the requirement for large amounts of protein will limit clinical testing of autoantigens, which are difficult to produce. We have previously demonstrated transgenic plant...
objectives: ctxb (cholera toxin b subunit) contributes to a vaccine's efficacy by stimulating production of the anti-ctxb antibody. various attempts have been made to increase production of this antibody. chitosan is a mucoadhesive polysaccharide that has tremendous potential for oral vaccine delivery in terms of its exclusive features that include biocompatibility, biodegradability, high charg...
Emerging evidences indicate that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin-converting enzyme 2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to the pathogenesis of pulmonary hypertension (PH). However, long-term repetitive delivery of ACE2 or Ang-(1-7) would require enhanced protein stability and ease of...
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery could, for example, allow topical treatment of inflammatory bowel disease. Treatment could be made more effective if it were possible for drugs to be targeted directly on the colon. Systemic side effects could also be reduced. Colon specific systems might also allow oral administration of peptide ...
Oral delivery of rifampicin through chitosan nanoparticles.
objective: dna vaccines have been widely used to develop immunity against various pathogens including parasites and viruses. the potential of dna vaccine to induce an effective immune response is related to the expression levels of the encoded protein in eukaryotic cells. therefore, optimization of plasmid dna delivery system is a major concern in protein expression in order to make an efficien...
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