a bstract background: in recent years, the lack of organ for transplantation has resulted in health planners and authorities in all countries, including iran, paying serious attention to the issue. despite the above-mentioned fact, families with a member affected by brain death are not interested in organ donation. objective: this study is aimed at making an investigation into the decision-maki...

Background: Septic acute kidney injury (AKI), identified when sepsis and AKI present concurrently, is a syndrome of function impairment organ damage, which accounts for ~50% in the intensive care unit (ICU).

Disturbance of each of the three hypothalamic-pituitary-end organ systems [hypothalamic-pituitary-thyroid (HPT), -adrenal (HPA), and -gonadal (HPG)] has been reported in depressive disorders. Little is known about potential reciprocal interaction among the three HP-end organ systems in patients with depressive disorders. The present pilot study examined selective HPA and HPG hormones in a detai...

Chronic progressive renal function loss is a main cause of long-term graft loss after initially successful renal transplantation. Transplanted kidneys share some risk factors for renal function loss, such as hypertension or proteinuria, with diseased native kidneys. Recently, it has been shown that renal function loss is influenced by the angiotensin-converting enzyme (ACE)(insertion/detection ...

Sensory organs are composed of neurons, which convert environmental stimuli to electrical signals, and glia-like cells, whose functions are not well understood. To decipher glial roles in sensory organs, we ablated the sheath glial cell of the major sensory organ of Caenorhabditis elegans. We found that glia-ablated animals exhibit profound sensory deficits and that glia provide activities that...

Evaluation methods are required for non-heart-beating donor (NHBD) kidneys to ensure the success of transplantation. In this study, the microdialysis technique was employed for the ex-vivo assessment of hypothermically preserved NHBD kidney function. Microdialysis probes were placed in the renal cortex of 2 h warm ischaemic porcine kidneys to monitor interstitial pyruvate dynamics during hypoth...

brain death is defined as the permanent, irreversible and concurrent loss of all brain and brain stem functions. brain death diagnosis is based on clinical criteria and it is not routine to use paraclinical studies. in some countries, electroencephalogram (eeg) is performed in all patients for the determination of brain death while there is some skepticism in relying on eeg as a confirmatory te...