This case study discusses the incidence of a paraneoplastic autonomic neuropathy in an elderly male who had otherwise negative work-up for their aetiology orthostatic hypotension. illustrates importance trying to correctly identify hypotension, which is often overlooked, and frequently diagnosed as idiopathic. Orthostatic hypotension most prevalent populations can be debilitating, leading highe...

Since indomethacin may be effective in the treatment of orthostatic hypotension, the ability of this drug to increase reflex vasoconstriction was studied in six patients with orthostatic hypotension and in five normal subjects. Reflex forearm vasoconstriction during lower body negative pressure at 20-40 mm Hg was measured before and after indomethacin 50 mg by mouth. In patients with orthostati...

Postural changes in 258 patients with pulmonary arteriovenous malformations (PAVMs) reviewed between 2005 and 2013 were evaluated prospectively using validated pulse oximetry methods. Of the 257 completing the test, 75 (29%) demonstrated orthodeoxia with an oxygen saturation fall of at least 2% on standing. None described platypnoea (dyspnoea on standing). The heart rate was consistently higher...

Orthostatic hypotension (OH) and supine hypertension (SH) are two cardiovascular symptoms of autonomic failure that frequently coexist in the same patient.
 Clinicians faced with a dilemma because aggressive orthostatic intolerance treatment can exacerbate hypertension, vice versa for management.
 The objective our article is to provide better framework clinical evaluation, right choi...

Spinal cord injury is a devastating chronic condition resulting in temporary or permanent motor,sensory or autonomic dysfunction of the cord. The manifestation of spinal cord injury based onthe severity and involved areas could be different. Numerous studies have demonstrated thatbradycardia, hypotension, and orthostatic hypotension are present insignificant number ofpat...

The inability to compensate for acute central hypovolemia underlies the clinical development of orthostatic hypotension and instability (e.g., syncope). Although neuro-humoral control of both cardiac output and peripheral vascular resistance contributes to hemodynamic stability during orthostasis, a notion has been proposed that the failure of adequate peripheral vascular constriction rather th...

BACKGROUND AND PURPOSE Patients with orthostatic hypotension due to sympathetic failure become symptomatic when standing, although their capability to maintain cerebral blood flow is reported to be preserved. We tested the hypothesis that in patients with sympathetic failure, orthostatic symptoms reflect reduced cerebral perfusion with insufficient oxygen supply. METHODS This study addressed ...

AIM To determine whether inappropriately secreted vasodilatory peptides have a role in the pathogenesis of orthostatic (postural) hypotension, a recognised paraneoplastic effect of bronchial malignancies usually attributed to immune mediated destruction of autonomic ganglia. METHODS Serum concentrations of three vasodilatory peptides, atrial natriuretic peptide (ANP), vasoactive intestinal po...

Introduction Orthostatic hypotension is a relatively common symptom caused by a variety of aetiologies. The most common of these are: neuropathies due to systemic diseases such as diabetes, amyloidosis and porphyria; vaso-vagal attacks; hypovolaemia; ShyDrager syndrome (idiopathic orthostatic hypotension); adverse effects of anti-adrenergic drugs, L-dopa and dopaminergic drugs; phaeochromocytom...