The present study investigates whether a minimal manipulation in task demands can induce core linguistic combinatorial mechanisms to extend beyond the bounds of normal grammatical phrases. Using magnetoencephalography, we measured neural activity evoked by the processing of adjective-noun phrases in canonical (red cup) and reversed order (cup red). During a task not requiring composition (verif...

The present study investigates whether a minimal manipulation in task demands can induce core linguistic combinatorial mechanisms to extend beyond the bounds of normal grammatical phrases. Using magnetoencephalography, we measured neural activity evoked by the processing of adjective-noun phrases in canonical (red cup) and reversed order (cup red). During a task not requiring composition (verif...

In a role distinct from and perhaps more ancient than that in signal transduction, PIP3 and Ras help to spatially organize the actin cytoskeleton into macropinocytic cups. These large endocytic structures are extended by actin polymerization from the cell surface and have at their core an intense patch of active Ras and PIP3, around which actin polymerizes, creating cup-shaped projections. We h...

The aim of this study was to evaluate the influence of disintegration mechanism of various types of disintegrants on the absorption ratio (AR), wetting time (WT), and disintegration time (DT) of orodispersible tablets (ODTs). ODTs were prepared by direct compression using mannitol as filler and disintegrants selected from a range of swellable, osmotic, and porous disintegrants. Tablets formed w...

Swellable elementary osmotic pump (SEOP)utilizes the osmotic pressure and polymer-swelling force to deliver drugs to the GI tract in a reliable and reproducible manner.Metoprolol and ramipril are one of the combinationsindicated in the management of hypertension in patients with heart failure and post myocardial infarction. This combination was selected to develop SEOP to release the drugs cont...

Translational repression of maternal mRNAs is an essential regulatory mechanism during early embryonic development. Repression of the Drosophila nanos mRNA, required for the formation of the anterior-posterior body axis, depends on the protein Smaug binding to two Smaug recognition elements (SREs) in the nanos 3' UTR. In a comprehensive mass spectrometric analysis of the SRE-dependent repressor...

This paper proposes a design of SMA-based bionic suction cup actuator, the core of which is that the bias spring cooperates with the SMA spring to produce a displacement at the varying temperature caused by the drive current. To characterize the dynamic drive performance of the actuator, the thermody‐ namic model is established by the constitutive model of SMA material of Tanaka series. The sim...

PURPOSE Find a novel delivery system for oral administration of drugs that have absorption window in the upper part of gastrointestinal (GI) track. METHODS Dipyridamole was chosen as the model drug. A novel system, which combined the osmotic pump controlled release system and the floating system, was designed; matrix tablets (MT) were prepared for compares. The effects of pH, temperature and ...

Wikipedia’s category graph is a network of 400,000 interconnected category labels, and can be a powerful resource for many classification tasks. However, its size and the lack of order can make it difficult to navigate. In this paper, we present a new algorithm to efficiently explore this graph and discover accurate classification labels. We implement our algorithm as the core of a query classi...

Background: Oral feeding problems are among the most common issues in preterm infants. Various methods and feeding support tools are used in this regard, such as cup feeding and feeding nozzle. The present study aimed to determine the preferred method between cup feeding and feeding nozzle to support oral feeding in premature neonates. Methods: This clinical trial was conducted on 70 preterm i...