Orthopedic treatments are amongst the most common cause of surgery and are responsible for a large share of global healthcare expenditures. Engineering materials that can hasten bone integration will improve the quality of life of millions of patients per year and reduce associated medical costs. Here, we present a novel hierarchical biomimetic coating that mimics the inorganic constituent of m...

Incorporation of phosphate groups into a material may be of particular interest as they act as templates for hydroxyapatite growth through complexation with Ca(2+) and thus improve the osteoconduction property. The phosphate groups can be incorporated into chitosan through ionotropic gelation with tripolyphosphate (TPP). Interestingly, the ion pairs formed through negatively charged phosphate g...

For years, in order to improve bone regeneration and prevent the need of a second stage surgery to remove non-resorbable membranes, biological absorbable membranes have gradually been developed and applied in guided tissue regeneration (GTR). The present study's main objective was to achieve space maintenance and bone regeneration using a new freeze-dried developed porcine collagen membrane, an...

Calcium phosphates are used in maxillary sinus floor elevation (MSFE) procedures to increase bone height prior to dental implant placement. Whether a collagenous barrier membrane coverage of the lateral window affects bone formation within a bone substitute augmentation is currently an important matter of debate, since its benefit has not been irrefutably proven. Therefore, in this clinical stu...

search between a Dutch group and a group in Chengdu, China,4,5 revealed that similar bone formation was seen with porous ceramics of various types of hydroxyapatite, tricalcium phosphate, and Bioglass® (NovaBone Products, Alachua, FL, USA). Fujibayashi and others in our department6 also reported that porous titanium processed with alkali-heat treatment has osteoinduction. This material contains...

We cultured human bone-derived mesenchymal stem cell(MSC)s (HMS0014:Yub621b) on a 3D collagen gel scaffold (Cellmatrix Type I-A) under non-inducing and inducing conditions in vitro. Conventional transmission electron microscopy (TEM) was performed for studying turnover of the MSCs and extracellular matrix (ECM) scaffold. The non-induced MSCs were fibroblast-like cells containing a variable numb...

l P ( p u d F m S P r B t e l ( b P W i p p a latelet-rich plasma (PRP) is an autologous concentraion of human platelets in a small volume of plasma. herefore, the term PRP is preferred to autologous latelet gel, plasma-rich growth factors (PRGFs), or a ere autologous platelet concentrate. Because it is a oncentration of platelets, it is also a concentration of he 7 fundamental protein growth f...

Coating the surface of titanium implants or other bone graft substitute materials with calcium phosphate (Ca-P) crystals is an effective way to enhance the osteoconduction of the implants. Ca-P coating alone cannot confer pro-osteodifferentiation and antibacterial capabilities on implants; however, it can serve as a carrier for biological agents which could improve the performance of implants a...

PURPOSE Poly(lactic-co-glycolic acid) (PLGA) is excellent as a scaffolding matrix due to feasibility of processing and tunable biodegradability, yet the virgin scaffolds lack osteoconduction and osteoinduction. In this study, nano-hydroxyapatite (nHA) was coated on the interior surfaces of PLGA scaffolds in order to facilitate in vivo bone defect restoration using biomimetic ceramics while keep...