It has recently been proposed that Earth-like planets in the outer regions of the habitable zone experience unstable climates, repeatedly cycling between glaciated and deglaciated climatic states (Menou 2015). While this result has been confirmed and also extended to explain early Mars climate records (Haqq-Misra et al. 2016; Batalha et al. 2016), all existing work relies on highly idealized ze...

Compensatory adrenal growth after unilateral adrenalectomy (ULA) leads to adrenocortical hyperplasia. Because zonal growth contributions are not clear, we characterized the phenotype of cortical cells that proliferate using immunofluorescence histochemistry and zone-specific cell counting. Rats underwent ULA, sham adrenalectomy (sham), or no surgery and were killed at 2 or 5 days. Adrenals were...

Both inner follicle cells and test cells in the tunicate ovary appear to engage in active synthesis and secretion during growth of the oocyte. Both cell types contain prominent Golgi systems, numerous vesicles and cisternae of endoplasmic reticulum, and typical mitochondria. Two types of special inclusions develop in the inner follicle cells. The first is a homogeneous inclusion of low density ...

PURPOSE To examine the features of the tapetal-like reflex (TLR) in female carriers of RPGR-associated retinopathy by means of adaptive optics scanning light ophthalmoscopy (AOSLO) and spectral domain optical coherence tomography. METHODS Nine molecularly confirmed RPGR carriers and three healthy controls underwent ocular examination and the following retinal imaging modalities: color photogr...

To assess the contribution of apoptosis to the mechanism of synovial joint cavitation, and to clarify morphological cellular changes during cavitation, we investigated the development of the rat knee joint by light and electron microscopy, TUNEL methods, and electrophoresis of DNA fragments. Although cavitation occurred within the interzone, which consists of 2 outer and a middle layer termed t...

Little is known of the molecular basis for the diversity of microtubule structure and function found within the eukaryotic flagellum. Antibodies that discriminate between tyrosinated alpha tubulin and post-translationally detyrosinated alpha tubulin were used to localize these complementary tubulin isoforms in flagella of the single-celled green alga Chlamydomonas reinhardtii. Immunofluorescenc...

Radial glia cells function as neural stem cells in the developing brain and generate self-renewing and differentiating daughter cells by asymmetric cell divisions. During these divisions, the apical process or basal process of the elongated epithelial structure is asymmetrically partitioned into daughter cells, depending on developmental contexts. However, in mammalian neurogenesis, the relatio...

Limiting dome height (LDH) tests were used to evaluate the formability of laser butt welded blanks of the dual phase 980 steel in comparison with the base metal. Two different lasers were used: diode and Nd:YAG, giving a wide range of welding thermal cycles. A sharp decrease in LDH was observed in the welded specimens due to the formation of a softened zone in the outer heat affected zone. Soft...

Magnetic resonance imaging (MRI) of the prostate was accomplished in 23 patients who had prostatic cancer histologically proved by needle biopsy. Five prostates resected out of 23 patients with prostatic cancer were available for in vitro MRI. The MRI findings of the normal peripheral zone of the prostate had a high signal intensity on T2 weighted image, and the cancer nests in the peripheral z...

The lateral (along trench axis) variation in the mode of large earthquake occurrence near the northern Japan Trench is explained by the variation in surface roughness of the subducting plate. The surface roughness of the ocean bottom near the trench is well correlated with the large-earthquake occurrence. The region where the ocean bottom is smooth is correlated with 'typical' large underthrust...