The corpus luteum is a temporary endocrine structure in mammals that plays an important role in the female reproductive cycle and is formed from a ruptured and ovulated follicle with rapid angiogenesis. Vascular endothelial growth factor (VEGF) is thought to be vital in normal and abnormal angiogenesis in the ovary, but the molecular regulation of luteal VEGF expression during corpus luteum dev...

Therapy advances are constantly improving survival rates of cancer patients, however the toxic effects of chemotherapy drugs can seriously affect patients' quality of life. In women, fertility and premature ovarian endocrine dysfunction are of particular concern. It is urgently we find methods to preserve or reconstruct ovarian function for these women. This study compares GnRHa treatment with ...

Primary ovarian insufficiency is the depletion or dysfunction of ovarian follicles with cessation of menses before age 40 years. There is no consensus on criteria to identify primary ovarian insufficiency in adolescents, and delay in diagnosis is common. Health care providers who make this clinical diagnosis should be mindful of the sensitive nature of this medical condition. Patients and their...

BACKGROUND Telomeres protect chromosomal ends, shorten with cellular division, and signal cellular senescence, but unchecked telomere attrition can lead to telomere dysfunction, upregulation of telomerase, and carcinogenesis. Shorter telomeres in peripheral blood leukocytes (PBL) have been associated with elevated cancer risk. Furthermore, genetic variants in and around the TERT gene have been ...

A patient is described with 45 XO Turner's syndrome and thin bones. It transpired that the patient had osteomalacia due to gluten sensitive enteropathy rather than the osteroporosis usually expected with Turner's syndrome. In addition, she had unexplained liver dysfunction. Causes for thin bones other than the osteoporosis associated with ovarian agenesis should be considered in patients with T...

The role of BRCA1 in breast and ovarian tumor suppression has been primarily ascribed to the maintenance of genome integrity. BRCA1 interacts with components of the non-homologous end-joining pathway previously shown to play a role in telomere maintenance in yeast. Here, we provide evidence that links Brca1 with telomere integrity. Brca1(-/-) T-cells display telomere dysfunction in both loss of...

The thyroid dysfunction, which is quite prevalent in the population, affects many organs including male and female gonads, thus interfering with the human reproductive physiology. Prolactin has suppressive effect on the pituitary –ovarian axis and may result in amenorrhea or oligomenorrhea due to anovulatory cycles. Hyperprolactinemia is a common problem in reproductive dysfunction, affecting a...

Deficiency of vitamin D3 has become common in both developed and developing countries. Vitamin D receptors are found on the granulosa cells ovarian tissue its deficiency plays a role dysfunction. Anti Mullerian Hormone (AMH) is generated small growing follicles ovaries by cells. Serum AMH one marker for reserve. We reviewed current literature present clinical practice. There relationship betwee...

s The thyroid dysfunction, which is quite prevalent in the population, affects many organs including male and female gonads, thus interfering with the human reproductive physiology. Prolactin has suppressive effect on the pituitary –ovarian axis and may result in amenorrhea or oligomenorrhea due to anovulatory cycles. Hyperprolactinemia is a common problem in reproductive dysfunction, affecting...

Endocrine function was assessed in 31 children (17 boys) after fractionated total body irradiation used in the preparative regimen for bone marrow transplantation. Endocrine dysfunction was present in 25 children. Fifteen of 29 had growth hormone insufficiency 0.9-4.9 years after total body irradiation, yet only three of the 15 had received previous cranial irradiation. Five of 30 had thyroid d...