The purpose of the work was to reveal role sex factors in processes lipid peroxidation (LPO) against background chronic ethanol-tetrachloromethane-induced liver damage and hepatotropic effects triple antiulcer therapy cryopreserved placenta extract (CEP). Chronic induced by introduction a CCl4 solution combination with an ethanol for 45 days. content reactants thiobarbituric acid (TBA-active pr...

Renal ischemic reperfusion Injury (I/R) is an important clinical problem that shows sex differences thus there was a specific role of sex steroids in renal injury. This study aimed to investigate the protective effect of estrogen as an antiinflammatory and anti-oxidant agent in renal I/R injury. Five groups were included (n=10/group): Sham-operated, I/R of the kidney, I/R after bilateral ovarie...

Estrogen deficiency impairs intestinal Ca absorption and induces bone loss, but its effects on the vitamin D-endocrine system are unclear. In the present study, calciotropic hormones levels, renal vitamin D metabolism, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]-dependent intestinal calcium absorption, and bone properties in 3-mo-old sham-operated (sham) or ovariectomized (OVX) rats fed either a nor...

ABSTRACT Early detection of osteoporosis using advanced imaging is imperative to the successful treatment and prevention high morbidity fractures in aging patients. In this preclinical study, we aimed compare dual‐energy X‐ray absorptiometry (DXA) quantitative computed tomography (QCT) quantify bone mineral density (BMD) changes sheep lumbar spine. We also determine relationship BMD microarchit...

Gonadal steroid hormones such as estrogen and progesterone can no longer be considered strictly within the confines of reproductive function, and with respect to their anatomic targets, extrahypothalamic structures within the brain such as the cerebral cortex have revealed themselves to be important targets. As such, it may come as no surprise that the decline in such hormones, which occurs aft...

Phytoestrogens have been implicated in the prevention of bone loss in postmenopausal osteoporosis. Recently, an active phytoestrogen from Curcuma comosa Roxb, diarylheptanoid (DPHD), (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol, was found to strongly promote human osteoblast function in vitro. In the present study, we demonstrated the protective effect of DPHD on ovariectomy-induced bone loss (...

This study was performed to determine the optimal window of time during which the properties of osteoporosis are obvious and to explore the best region of interest for microstructural evaluation in antiosteoporosis research in an ovariectomized mouse model by examining changes in micro-computed tomography parameters and serum indices. Ovariectomized mice and sham-operated mice were randomly div...

The present study was undertaken to test whether long term administration of HEBP could prevent the progress of bone loss induced by ovariectomy in rats. Administration of HEBP was started from day 111 after ovariectomy. The animals received subcutaneous injections of HEBP, at a dose of 0, 2, 4, or 8 mg/kg, every other day for 92 days. Tibiae, femora and incisor teeth were investigated by chemi...

This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemi...

Female Sprague–Dawley rats were ovariectomized at 13 months of age. Four groups received different regimens of estrogen or estrogen plus progesterone replacement beginning either immediately, 3 months, or 10 months after ovariectomy and were compared with non-hormone-treated controls. Eight to twelve months after ovariectomy, animals were trained on a delayed matching-to-position (DMP) spatial ...