Inhibitor of differentiation (Id) proteins act during embryogenesis and development to repress gene transcription required for lineage commitment, while promoting cell growth. Growth factors belonging to the TGFbeta superfamily of signaling molecules, notably the bone morphogenetic proteins (BMPs) and activin, can regulate Id expression in these tissues. Id expression and function in adult phys...

The open reading frame of black tiger shrimp (Penaeus monodon) cyclin B (Pmcyclin B) was identified, based on cDNA sequence registered in GenBank (accession No. EF015590). The target sequence was 1206 bp, corresponding to 401 amino acids. Two conserved signature sequences of the cyclin B gene family were found in the Pmcyclin B deduced aa sequence. Temporal expression of Pmcyclin B in different...

OBJECTIVE To observe the therapeutic effects of Jinqi Jiangtang Tablet (JQJTT), a commonly prescribed recipe for type 2 diabetes in traditional Chinese medicine, on obese women with polycystic ovary syndrome (PCOS). METHODS Twenty-four obese women with PCOS were prescribed JQJTT for 3 months and the changes of carbohydrate metabolism and biochemical indicators, including menstrual cycle, body...

In order to evaluate the expression profile of follicle-stimulating hormone receptor (FSHR) mRNA in the ovary of Zi geese during developmental and egg laying stages, the expression levels of FSHR mRNA in the ovary of Zi geese at the ages of 1 day, 1, 2, 3, 4, 5 and 8 months (n=8, respectively) were examined by quantitative real-time PCR (qRT-PCR). The results showed that FSHR mRNA expression wa...

Background: Adequate nutritional status is a critical determinant of the onset and maintenance of normal reproductive function. More than 50% of women with PCOS are obese and central obesity plays a central role in the pathogenesis of PCOS by generating an insulin- resistant state, It has been proposed that recurrent hypoglycaemia due to hyperinsulinaemia could lead to decreased post-prandial s...

Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulation, infertility and hyperandrogenism in women, affecting 5-10% of women of reproductive age. Due to the ethical limitations on human experimentation, appropriate animal models that mimic many or all PCOS characteristics would facilitate research leading to improved understanding of the pathogenesis of PCOS...

Mitomycin C is an alkylating agent used in cancer chemotherapy that shows some specificity towards hypoxic cells. The therapeutic effects of this compound are thought to result from its metabolic activation by enzymes such as NADPH:cytochrome P-450 reducÃ-ase.In a previous report we described a Chinese hamster ovary cell line resistant to mitomycin C, which had a decreased NADPH:cytochrome P-45...

Mitomycin C is an alkylating agent used in cancer chemotherapy that shows some specificity towards hypoxic cells. The therapeutic effects of this compound are thought to result from its metabolic activation by enzymes such as NADPH:cytochrome P-450 reductase. In a previous report we described a Chinese hamster ovary cell line resistant to mitomycin C, which had a decreased NADPH:cytochrome P-45...