To examine the potential role of endothelium-derived relaxing factor (EDRF) in regulation of the perinatal pulmonary circulation, we studied the hemodynamic effects of a selective inhibitor of EDRF production, nitro-L-arginine (L-NA), on pulmonary vascular tone and dilator reactivity in the late-gestation ovine fetus and on the pulmonary vasodilation that normally occurs at birth. L-NA infusion...

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is considered the only type of pulmonary hypertension (PH) with a potentially curative surgical treatment. Even today, this pathology is not easily recognized and frequently diagnosis is delayed, with the consequent impairment of the prognosis. CTEPH presents with nonspecific symptoms and general practitioners may not be aware of the conditi...

High levels of circulating catecholamines are found in the fetus, and fetal stress and birth induce a marked surge in catecholamine secretion. Little is known about the role of catecholamines on the fetal pulmonary circulation. To determine the effects of catecholamines on the pulmonary vascular tone, we tested the hemodynamic response to norepinephrine and dopamine infusion in chronically prep...

Ovine pulmonary adenocarcinoma (OPA) is a contagious and transmissible lung cancer of sheepresembling human bronchiolo-alveolar carcinoma. In the present study, lungs of 9400 sheep slaughtered inFars province, Iran were examined morphopathologically. The OPA was diagnosed in the lungs of 21(0.22%) out of 9400 sheep. Frequency of involvement of different lobes in the affected lungs was includeda...