background and objectives: carbapenem resistant a. baumannii is an emerging cause of nosocomial infections. the aims of this study were identification of the most prevalent of carbapenem resistant genes, molecular typing and antimicrobial evaluation of a.baumannii in intensive care units. materials and methods: two hundred and six a. baumannii were isolated from tracheal tube discharge of hospi...

Supplementary data at JAC Online). An additional promoter was predicted by Softberry BPROM promoter prediction and consisted of the 235 box of IS18 and a 210 box separated by 13 bp (Figure S1, available as Supplementary data at JAC Online). 10 Interestingly , the TTCAAT 235 box identical to that from Baz (bla OXA-228) was adjacent to the left inverted repeat. OXA-228-like expression in isolate ...

To the Editor: Nordmann et al. (1) raised concern over the global spread of carbapenemase-producing Enterobacteriaceae. In their article, they called attention to the oxacillinase-48 (OXA-48) type carbapenemases because bacteria that produce these enzymes do not have a distinctive antimicrobial drug susceptibility profi le, and there is less awareness of this mechanism of carbapenem resistance....

BACKGROUND The aim of this study was to characterize the spread of carbapenemase-producing Klebsiella pneumoniae (CPKP) in a tertiary level hospital using ongoing active surveillance with rectal swab cultures. Furthermore, this study analyzed the presence of CPKP in the clinical samples (CS) of a single patient as well as the evolution of Colistin-sensitive strains (CoS) to Colistin-resistant s...

Nosocomial infections caused by Acinetobacter spp. resistant to carbapenems are increasingly reported worldwide. Carbapenem-resistant Acinetobacter (CRA) is becoming a serious concern with increasing patient morbidity, mortality, and lengths of hospital stay. Therefore, the rapid detection of CRA is essential for epidemiological surveillance. Polymerase chain reaction (PCR) has been extensively...

Correspondence Emergence of an Autochthonous and Community-Acquired NDM-1–Producing Klebsiella pneumoniae in Europe To the Editor—The recently identi-tified carbapenemase New Dehli metallo-b-lactamase (NDM-1) in-activates all b-lactams except az-treonam [1]. The corresponding gene that is usually plasmid-borne has spread mostly in Escherichia coli and Klebsiella pneumoniae [1, 2]. NDM-1 produce...

To the Editor: Carbapenemase-producing Enterobacteriaceae are being reported worldwide. Travel, medical tourism, and cross-border transfer of patients might play a role in the spread of these bacteria (1,2). Klebsiella pneumoniae co-producing New Delhi metallo-β-lactamase 5 (NDM-5) and oxacillinase 181 (OXA-181) carbapenemases was detected in South Korea in 2014. On April 13, a 75-year-old man ...

Sir, IMP-13 is a class B metallo-b-lactamase that was first described in a carbapenem-resistant clinical isolate of Pseudomonas aeruginosa from Italy. The IMP-13 gene was mostly described as part of the class 1 InPSG integron located on a Tn5051 transposon, and it was reported in intercontinentally disseminating P. aeruginosa of sequence type 621 causing outbreaks in Italy, Romania and Argentin...

Sir, In 2002, we saw the emergence of carbapenem resistance in clinical isolates of Acinetobacter baumannii isolated from patients at two local hospitals, Groote Schuur Hospital (GSH) and Tygerberg Hospital (TH), Western Cape, South Africa. The high levels of imipenem (16–256 mg/L) and meropenem (>32 mg/L) resistance observed in these A. baumannii isolates suggested the presence of a metallo-b-...