Schizophrenia is a devastating psychiatric disorder that affects 1% of population worldwide. Neuroleptics are the major class of drugs used in the treatment of schizophrenia. Neuroleptics are associated with wide variety of extrapyramidal side effects such as akathesia, dystonia, neuroleptic malignant syndrome, Parkinsonism and tardive dyskinesia. tardive dyskinesia is a complex hyperkinetic sy...

Schizophrenia is a devastating psychiatric disorder that affects 1% of population worldwide. Neuroleptics are the major class of drugs used in the treatment of schizophrenia. Neuroleptics are associated with wide variety of extrapyramidal side effects such as akathesia, dystonia, neuroleptic malignant syndrome, Parkinsonism and tardive dyskinesia. tardive dyskinesia is a complex hyperkinetic sy...

Background: Multiple organ dysfunctions have been linked to exposure to polycyclic aromatic hydrocarbons (PAH) and oxidative stress (OS), oxidative DNA damage, and inflammatory response to PAH have been implicated. The biomarkers of OS (malondialdehyde (MDA), total plasma peroxide (TPP), total antioxidant capacity (TAC), glutathione (GSH), nitric oxide (NO), oxidative stress index (OSI)); 8-hy...

The aim of this article is to present the current state of knowledge in the field of cognitive dysfunctions in bipolar disorders (BD). These dysfunctions are considered to be a result of brain activation disorders and occur in such domains as attention, psychomotor speed, visuospatial abilities, different aspects of executive functions (e.g. cognitive flexibility, reaction inhibition), decision...

This paper presents an industrial application of “Dysfunction Mode and Effects Critical Analysis” (DMECA) to determine and analyze possible dysfunctions in a complex management process. The approach conceptually derived from the Failure Mode and Effect Critical Analysis (FMECA) technique. DMECA enables user to analyze all possible dysfunctions of management processes, identify the subsequent ef...

In psoriasis, keratinocytes of the healthy-looking uninvolved skin are more sensitive to stress. Our previous study suggested that cell-stress proteins showing altered expression in psoriatic vs. healthy can affect mitochondrial functions. Therefore, we aimed examine whether involved these alterations, and compared functions between cultured detail by high–resolution respirometry. We did not fi...

• Natural products promote healthspan in rodent models of physiological ageing. Oxidative stress is a target natural products. Both brain and peripheral tissues benefit from treatment with Positive effects are observed on cognition as well physical performance. Over the last decades decrease mortality has paved way for late onset pathologies such cardiovascular, metabolic or neurodegenerative d...

Parkinson’s Disease (PD), the second most frequent neurodegenerative disorder after Alzheimer’s disease (six million patients world-wide), is generally diagnosed after the sixth decade. It causes motor dysfunctions, such as bradykinesia, resting tremor, rigidity and postural instability, but also affects autonomic functions and cognition. PD results mainly from progressive degeneration of dopam...