Amyloid-like inclusions have been associated with Huntington's disease (HD), which is caused by expanded polyglutamine repeats in the Huntingtin protein. HD patients exhibit a high incidence of cardiovascular events, presumably as a result of accumulation of toxic amyloid-like inclusions. We have generated a Drosophila model of cardiac amyloidosis that exhibits accumulation of PolyQ aggregates ...

The relentless increase in the demand for useable power from energy-hungry economies continues to drive energy-material related research. Fuel cells, as a future potential power source that provide clean-at-the-point-of-use power offer many advantages such as high efficiency, high energy density, quiet operation, and environmental friendliness. Critical to the operation of the fuel cell is the ...

Campylobacter jejuni is the leading cause of bacterial gastroenteritis in the developed world. Despite its prevalence, relatively little is known about C. jejuni's precise pathogenesis mechanisms, particularly in comparison to other well-studied enteric organisms such as Escherichia coli and Salmonella spp. Altered expression of phosphate genes in a C. jejuni stringent response mutant, together...

Background Many patients suffering from depressive disorders are refractory to treatment with currently available antidepressant medications, while many more exhibit only a partial response. These factors drive research to discover new pharmacological approaches to treat depression. Numerous studies demonstrate evidence of inflammation and elevated oxidative stress in major depression. Recently...

The artificial DNase activity of the 1,10-phenanthroline-cuprous ion complex [(OP)2Cu+] and H2O2 cleaves the A, B, and Z forms of DNA at different rates. The B structure, formed by most DNAs including poly(dA-dT) and poly(dA) X poly(dT), is the most susceptible to cleavage. It is completely degraded within 1 min by 40 microM 1,10-phenanthroline/4 microM Cu2+/7 mM H2O2/7 mM 3-mercaptopropionic a...

oxidative stability of walnut (juglansregia l.) was evaluated over a period of 1 year storage in various conditions. the whole walnuts, walnut kernels, walnut chopped kernels, walnut kernels packaged in polyethylene (pet) under vacuum and poly propylene (pp) contain of co2 were kept in a normal condition (temperature, 19-30˚с and relative humidity (rh), 35-45%). the whole walnuts and walnut ker...

Solid polymer electrolytes (SPEs) are promising candidates for solid-state lithium-ion batteries. Potentially, they can be used with lithium metal anodes and high-voltage cathodes, provided that their electrochemical stability is sufficient. Thus far, the oxidative has largely been asserted based on results obtained sweep voltammetry, which often determined reliant arbitrary assessments highly ...

The highly conserved abundant nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) is activated by DNA damage. PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases, the attention towards PARP-1 as a therapeutic target has been amplifyin...